Anti-platelet aggregation activities of different fractions in leaves of Apocynum venetum L.
文献类型： 外文期刊
作者： Kasimu, Rena 1 ; Fan, Zhenzhen 1 ; Wang, Xinling 1 ; Hu, Junping 1 ; Wang, Peng 2 ; Wang, Jinhui 3 ;
作者机构： 1.Xinjiang Med Univ, Coll Pharm, Urumqi 830011, Xinjiang, Peoples R China
2.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Danzhou 571737, Hainan, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Shenyang 110016, Liaoning, Peoples R China
关键词： Multi-components;Apocynum venetum L;Anti-platelet aggregation
期刊名称：JOURNAL OF ETHNOPHARMACOLOGY （ 影响因子：4.36； 五年影响因子：4.488 ）
ISSN： 0378-8741
年卷期： 2015 年 168 卷
页码：
收录情况： SCI
摘要： Ethnopharmacological relevance Apocynum venetum: is widely used in Uygur and traditional Chinese medicine. Modern pharmaceutical studies have shown that leaves of A. venetum have effects of liver protection, antidepressant and regulation of blood pressure. However, it is unclear that which components have pharmacological activities. Aim of the study: The aim was to study chemical constituents of A. venetum and its anti-platelet aggregation activity. Materials and methods: Nephelometery was applied to evaluate anti-platelet aggregation activity of multi-components of A. venetum. Systematic separation components were characterized by HPLC analysis method, and in vitro screening active components by anti-platelet aggregation study. Results: Ethyl acetate fraction (L-III) and L-III-4 have better anti-platelet aggregation activity than other fractions. The results indicated that isoquercitrin, hyperoside and other flavonoids have anti-platelet aggregation activity in A. venetum. Conclusion: Our studies provide basis on the endeavors of screening chemicals with that anti-platelet aggregation activity in leaves of A. venetum. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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