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Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon

文献类型： 外文期刊

作者： Li, Puwang 1 ; Yang, Ziming 1 ; Wang, Yichao 2 ; Peng, Zheng 1 ; Li, Sidong 1 ; Kong, Lingxue 1 ; Wang, Qinghuang 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

2.Deakin Univ, Inst Frontier Mat, Geelong, Vic 3217, Australia

3.Natl Ctr Important Trop Crops Engn & Technol Res, Haikou, Peoples R China

关键词： 5-Fluorourical;colon cancer;drug delivery;leucovorin;microencapsulation

期刊名称：JOURNAL OF MICROENCAPSULATION （ 影响因子：3.142； 五年影响因子：2.933 ）

ISSN： 0265-2048

年卷期： 2015 年 32 卷 1 期

页码：

收录情况： SCI

摘要： Folate-chitosan nanoparticles, co-loaded with 5-fluourouacil (5-FU) and leucovorin (LV) and prepared by ionic gelation technology were physically microencapsulated by enteric polymer using a solvent evaporation method. Average particle size of the microencapsulated particles was in the range of 15 to 35 mm. High drug encapsulation efficiency was obtained for both 5-FU and LV in the microencapsulated particles. Both drugs were in amorphous state in the microencapsulated particles. By enteric coating, excellent pH-dependent release profile was achieved and no drug release was observed in simulated gastric and intestinal fluids. However, when the pH value reached the soluble threshold of Eudragit S-100, a constant and slow drug release was observed. The results indicated that these microencapsulated particles are a promising vehicle for selectively targeting drugs to colon in the chemotherapy of colon cancer.

  • 相关文献

[1]Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer. Wang, Yichao,Wang, Yichao,Li, Puwang,Thao Truong-Dinh Tran,Zhang, Juan,Kong, Lingxue,Li, Puwang,Thao Truong-Dinh Tran. 2016

[2]Simultaneous Incorporation of 5-Fluorouracil and Leucovorin into Chitosan Nanoparticle as Drug Carrier and Its Characterization. Li, Puwang,Wang, Yichao,Kong, Lingxue,Peng, Zheng,Kong, Lingxue. 2010

[3]Development of chitosan nanoparticles as drug delivery systems for 5-fluorouracil and leucovorin blends. Li, Puwang,Wang, Yichao,She, Fenghua,Kong, Lingxue,Li, Puwang,Peng, Zheng,Li, Puwang.

[4]Microencapsulation of lipase produced omega-3 concentrates resulted in complex coacervates with unexpectedly high oxidative stability. Xia, Qiuyu,Wang, Bo,Akanbi, Taiwo O.,Li, Rui,Yang, Wenrong,Barrow, Colin J.,Xia, Qiuyu,Li, Rui,Adhikari, Benu.

[5]Design of microencapsulated carbon nanotube-based microspheres and its application in colon targeted drug delivery. Zhou, Min,Peng, Zheng,Li, Puwang,Zhou, Min,Liao, Shuangquan,Li, Sidong.

[6]Nanogels fabricated by lysozyme and sodium carboxymethyl cellulose for 5-fluorouracil controlled release. Zhu, Kunkun,Ye, Ting,Liu, Jinjin,Xu, Shasha,Lei, Jieqiong,Deng, Hongbing,Li, Bin,Zhu, Kunkun,Ye, Ting,Liu, Jinjin,Xu, Shasha,Lei, Jieqiong,Deng, Hongbing,Li, Bin,Zhu, Kunkun,Peng, Zheng.

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