文献类型： 外文期刊
作者： Mei, Chen 1 ; Liu, Ying 1 ; Lyu, Xueze 2 ; Jiang, Zhaoling 1 ; Liu, Zhenyi 1 ; Zhi, Yan 1 ; Xu, Xiaolong 4 ; Wang, Hongjun 1 ;
作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100097, Peoples R China
2.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China
3.Beijing Gen Anim Husb Stn, Beijing 100107, Peoples R China
4.Capital Med Univ, Lab Clin Med, Beijing 100010, Peoples R China
关键词： isorhamnetin; malignant tumor; antitumor mechanism; clinical application; natural medicine
期刊名称：NUTRIENTS （ 影响因子：5.0； 五年影响因子：6.0 ）
ISSN：
年卷期： 2025 年 17 卷 11 期
页码：
收录情况： SCI
摘要： Isorhamnetin (ISO) is a natural flavonoid compound that has become a main research topic in recent years due to its multitargeted antitumor properties. In this paper, we systematically review the molecular basis of the inhibition of malignant tumors by ISO, including through the regulation of the cell cycle, PI3K/AKT/mTOR pathway, MAPK pathway, apoptosis/autophagy-related pathways, and the tumor microenvironment. We also explore its synergistic effects with chemotherapy/targeted therapies and its potential for clinical translation. Experimental studies have shown that ISO can not only directly inhibit tumor proliferation by inducing tumor cell cycle arrest, mitochondria-dependent apoptosis, and endoplasmic reticulum stress, but also enhance antitumor immune responses by regulating the immune microenvironment. Pharmacokinetic studies have shown that novel delivery systems, such as nano-formulations, significantly enhance the bioavailability of ISO. Notably, ISO has demonstrated unique advantages in attenuating the nephrotoxicity of chemotherapeutic agents, protecting normal cells, and reversing tumor resistance. However, the optimal dosing regimen, dose-effect relationship, and cross-species applicability need to be further validated by large-scale preclinical animal experiments and clinical trials. This paper provides a theoretical basis for the development and application of ISO for the treatment of malignant tumors and highlights its potential value in animal models.
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