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New Azalomycin F Analogs from Mangrove Streptomyces sp 211726 with Activity against Microbes and Cancer Cells

文献类型: 外文期刊

作者: Yuan, Ganjun 1 ; Hong, Kui 2 ; Lin, Haipeng 2 ; She, Zhigang 4 ; Li, Jia 5 ;

作者机构: 1.Jiangxi Agr Univ, Coll Biosci & Engn, Nanchang 330045, Peoples R China

2.Wuhan Univ, Sch Pharmaceut Sci, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan 430071, Peoples R China

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

4.Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

5.Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China

关键词: azalomycin F;Streptomyces sp 211726;cytotoxicity;antimicrobial activity

期刊名称:MARINE DRUGS ( 影响因子:5.118; 五年影响因子:5.951 )

ISSN: 1660-3397

年卷期: 2013 年 11 卷 3 期

页码:

收录情况: SCI

摘要: Seven new azalomycin F analogs (1-7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F-5a monoester (1), 23-valine demalonylazalomycin F-5a ester (2), 23-(6-methyl) heptanoic acid demalonylazalomycins F-3a ester (3), F-4a ester (4) and F-5a ester (5), 23-(9-methyl) decanoic acid demalonylazalomycin F-4a ester (6) and 23-(10-methyl) undecanoic acid demalony lazalomycin F-4a ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F-3a, F-4a and F-5a. Biological assays exhibited that 1-7 showed broad-spectrum antimicrobial and anti HCT-116 activities.

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