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Nimodipine alleviates apoptosis-mediated impairments through the mitochondrial pathway after spinal cord injury

文献类型： 外文期刊

作者： Cai, Yafei 1 ; Fan, Rui 1 ; Hua, Tianmiao 1 ; Liu, Huiling 1 ; Li, Jing 2 ;

作者机构： 1.Anhui Normal Univ, Coll Life Sci, Key Lab Biot Environm & Ecol Safety Anhui Prov, Wuhu 241000, Anhui, Peoples R China

2.Columbia Univ, Ctr Mol Recognit, New York, NY 10032 USA

3.Chinese Acad Trop Agr Sci, Spice & Beverage Crops Res Inst, Wanning 571533, Hainan, Peoples R China

关键词： Nimodipine;Mitochondrial-pathway;Alleviation;Spinal cord injury;Apoptosis

期刊名称：CURRENT ZOOLOGY （ 影响因子：2.624； 五年影响因子：3.026 ）

ISSN： 1674-5507

年卷期： 2011 年 57 卷 3 期

页码：

收录情况： SCI

摘要： Spinal cord injury (SCI) remains an unsolved human health challenge. To alleviate the impairments of SCI, we studied the therapeutic effect of nimodipine (an L-type Ca2+ channel antagonist) on functional recovery from SCI using Nystrom's method in a mouse model. Eighty-four mice were divided into three groups: control group in which only vertebral plates were cut off without causing any spinal injuries; SCI; and SCI with nimodipine treatment. We assessed the histopathology, apoptosis detection, cell cycle, mitochondrial transmembrane potential, bcl-2/bax and caspase-3 levels of tissue 8 h, 1 d, 3 d and 4 d after trauma to evaluate rehabilitation. Behavioral performances were also assessed before and after nimodipine treatment. Results from inclined plane tests, motor score assessment and histological observations indicated that mice in the nimodipine-treated group rehabilitated better than those in the SCI group. The ratio of apoptosis, caspase-3 and bax expression in the nimodipine-treated group were significantly lower than those in the SCI group. The mitochondrial membrane potential and bcl-2 expression were up-regulated in the nimodipine-treated group. Taken together, our results indicate that the inhibition of calcium flux by nimodipine could reduce apoptosis processes and tissue damage through a mitochondrial pathway after spinal cord trauma [Current Zoology 57 (3): 340-349, 2011].

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