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A new staurosporine analog from Actinomycetes Streptomyces sp (172614)

文献类型： 外文期刊

作者： Li, Xiao-Bin 1 ; Tang, Jin-Shan 1 ; Gao, Hao 1 ; Ding, Rong 2 ; Li, Jia 3 ; Hong, Kui 4 ; Yao, Xin-Sheng 1 ;

作者机构： 1.Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

2.Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China

4.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

关键词： Streptomyces sp.;staurosporine analog;cytotoxicity;HCT 116

期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）

ISSN： 1028-6020

年卷期： 2011 年 13 卷 8 期

页码：

收录情况： SCI

摘要： A new staurosporine analog, 10'-{5 ''-[(methoxycarbonyl) amino]-2 ''-methyl}-phenylaminocarbonylstaurosporine (1), together with staurosporine (2), was obtained from the culture broth of Actinomycetes Streptomyces sp. (172614). Their structures were elucidated by comprehensive spectroscopic analysis including UV, MS, NMR, and CD spectra. Pharmacological experiments revealed that 1 and 2 showed significant cytotoxicity against human colon tumor cell HCT-116.

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