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H-1 and C-13 assignments of two new macrocyclic lactones isolated from Streptomyces sp 211726 and revised assignments of Azalomycins F-3a, F-4a and F-5a

文献类型： 外文期刊

作者： Yuan, Ganjun 1 ; Lin, Haipeng 1 ; Wang, Cheng 1 ; Hong, Kui 1 ; Liu, Yue 4 ; Li, Jia 4 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Trop Microbial Resources, Haikou 571101, Peoples R China

2.Hainan Med Coll, Dept Pharm, Haikou 571101, Peoples R China

3.Hainan Univ, Coll Agr, Haikou 570228, Peoples R China

4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China

关键词： NMR;H-1 NMR;C-13 NMR;2D NMR;Azalomycin F-4a 2-ethylpentyl ester;Azalomycin F-5a 2-ethylpentyl ester;Streptomyces sp 211726;macrocyclic lactone

期刊名称：MAGNETIC RESONANCE IN CHEMISTRY （ 影响因子：2.447； 五年影响因子：1.925 ）

ISSN： 0749-1581

年卷期： 2011 年 49 卷 1 期

页码：

收录情况： SCI

摘要： Azalomycin F-4a 2-ethylpentyl ester (1) and Azalomycin F-5a 2-ethylpentyl ester (2), two new macrocyclic lactones, along with three known compounds of Azalomycins F-3a (3), F-4a (4) and F-5a (5), were identified from metabolites of Streptomyces sp. 211726 isolated from mangrove rhizosphere soil. The complete H-1 and C-13 assignments of these compounds were achieved by using H-1, C-13, DEPT, HSQC, H-1-H-1 COSY and HMBC spectra, and the relative stereochemistry of 5 was first elucidated on the basis of proton-proton coupling constants, NOESY and IR spectra. Moreover, some errors in the H-1 and C-13 assignments published of 3, 4 and 5 were found and revised. 1 and 2 were active against Candida albicans, and exhibited moderate cyctotoxicity against HCT-116 cell line. Copyright (C) 2010 John Wiley & Sons, Ltd.

  • 相关文献

[1]Azalomycin F-4a 2-ethylpentyl ester, a new macrocyclic lactone, from mangrove actinomycete Streptomyces sp 211726. Yuan, Gan Jun,Hong, Kui,Lin, Hai Peng,Yuan, Gan Jun,Li, Jia. 2010

[2]New Azalomycin F Analogs from Mangrove Streptomyces sp 211726 with Activity against Microbes and Cancer Cells. Yuan, Ganjun,Yuan, Ganjun,Hong, Kui,Lin, Haipeng,Yuan, Ganjun,Hong, Kui,She, Zhigang,Li, Jia. 2013

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