文献类型： 外文期刊

作者： Dai, HF ¹ ; Edrada, RA ² ; Ebel, R ² ; Nimtz, M ² ; Wray, V ³ ; Proksch, P;

作者机构： 1.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany

2.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany; Gesell Biotechnol Forsch mbH, D-38124 Braunschweig, Germany; Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, State Key Lab Trop Crops Biotechnol, Haikou 571101, Peoples R China

3.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany; Gesell Biotechnol Forsch mbH, D-38124 Braunschweig, Ger

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

ISSN： 0163-3864

年卷期： 2005 年 68 卷 8 期

页码：

收录情况： SCI

摘要： Along with five known 30-norlanostane-type saponins, sarasinosides A(1) (5A), A(3) (6A), h (7), 12 (8), and H-2 (9), four new triterpenoidal saponin congeners, sarasinosides J (1), K (2), L (3), and M (4), were isolated from the Indonesian sponge Melophlus sarassinorum. Sarasinosides J (1) and K (2) are the 24,25-hydrogenated congeners of the previously described sarasinosides A(1) and H-2, respectively. The carbon skeleton of sarasinoside M (4) possesses a rearranged 8 alpha,9 alpha-epoxy-8,9-seconorlanosta-8(14),9(11),24-triene system, which is novel and unprecedented in nature. The structures of the new compounds were confirmed by spectral analyses, chemical derivatization, and GC analyses. Compounds 1 and 5A exhibited antimicrobial activity toward Bacillus subtilis and Saccharomyces cerevisiae.