Methylation Alkynylation of Terminal Alkenes via 1,2-Alkynyl Migration Using Dicumyl Peroxide as the Methyl Source
文献类型： 外文期刊
作者： Qin, Yi-qun 1 ; Chen, De 1 ; Liu, Liang 1 ; Zhang, Jia-jia 1 ; Peng, Xin-ju 1 ; Luo, Yong-yue 2 ; Deng, Wei 1 ; Xiang, Ji 1 ;
作者机构： 1.Hunan Univ, Coll Chem & Chem Engn, Adv Catalyt Engineer Res Ctr Educ, Changsha 410082, Hunan, Peoples R China
2.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 440800, Peoples R China
关键词： alkene difunctionalization; migration reaction; radical
期刊名称：SYNTHESIS-STUTTGART （ 影响因子：3.157； 五年影响因子：2.743 ）
ISSN： 0039-7881
年卷期： 2021 年 53 卷 24 期
页码：
收录情况： SCI
摘要： The metal-free oxidative alkene methylation/alkynylation of 1,4-enyn-3-ols with an organic peroxide as the methyl source has been developed, which provides straightforward and practical access to the challenging quaternary-carbon-containing but-3-yn-1-ones. The method is reasoned to go through methylation of functional alkenes utilizing dicumyl peroxide as the methylating reagent and subsequent intermolecular cyclization/1,2-alkynyl migration. This reaction has an excellent functional group tolerance, broad substrate scope, and exquisite selectivity.
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