Cashew nut oligopeptide inhibits mast cell degranulation by suppressing activation of the NF-Κb signalling pathway
文献类型： 外文期刊
作者： Chen, Di 1 ; Zhou, Xin 1 ; Zhang, Yan 4 ; Chen, Jian 1 ;
作者机构： 1.Hainan Univ, Engn Res Ctr Utilizat Trop Polysaccharide Resource, Key Lab Food Nutr & Funct Food Hainan Prov, Minist Educ, Haikou 570228, Peoples R China
2.Hainan Univ, Coll Food Sci & Engn, Haikou 570228, Peoples R China
3.Chinese Acad Trop Agr Sci, Anal & Test Ctr, Haikou 571101, Peoples R China
4.Hainan Univ, State Key Lab Marine Resource Utilizat South China, Haikou 570228, Peoples R China
关键词： Cashew nut protein; Oligopeptides; Degranulation; Mast cell; NF-kappa B signalling pathway
期刊名称：FOOD CHEMISTRY-X （ 影响因子：8.2； 五年影响因子：8.2 ）
ISSN： 2590-1575
年卷期： 2025 年 29 卷
页码：
收录情况： SCI
摘要： This study aimed to isolate oligopeptides with anti-allergic properties from cashew nuts. Cashew nut protein was extracted using subcritical water extraction. Subsequently, cashew nut oligopeptides (COPs) were obtained via a two-step enzymatic hydrolysis involving alkaline proteinase and bromelain. Mass spectrometry analysis identified a specific COP with the sequence Ile-Ile-Ala-Ile-Pro-Ala-Gly-Val-Ala-His. This COP was synthesised to investigate its impact on preventing degranulation. Analysis revealed that COP effectively inhibited the release and production of proinflammatory mediators, including tumour necrosis factor-alpha, interleukin-6, histamine and (3-hexosaminidase and influx of extracellular calcium ions. Furthermore, COP significantly suppressed degranulation and inflammatory responses by inhibiting activation of nuclear factor kappa B signalling pathway in allergic mast cells. These findings suggest that COP possesses strong anti-allergic effects by specifically targeting mast cells degranulation. This s highlights COP's therapeutic potential against allergic inflammatory disorders, and its promising role in treating allergic diseases.
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