A nuclear-encoded endonuclease governs the paternal transmission of mitochondria in Cucumis plants
文献类型： 外文期刊
作者： Shen, Jia 1 ; Lyu, Xiaolong 2 ; Xu, Xinyang 1 ; Wang, Zheng 1 ; Zhang, Yuejian 1 ; Wang, Chenhao 2 ; Munaiz, Eduardo D. 5 ; Zhang, Mingfang 2 ; Havey, Michael J. 7 ; Shou, Weisong 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Vegetables, Hangzhou, Peoples R China
2.Key Lab Vegetable Germplasm Innovat & Qual Breedin, Hangzhou, Peoples R China
3.Zhejiang Univ, Coll Agr & Biotechnol, Lab Vegetable Germplasm Innovat & Mol Breeding, Hangzhou, Peoples R China
4.Zhejiang Univ, Coll Agr & Biotechnol, Lab Plant Genome & Evolutionary Biol, Hangzhou, Peoples R China
5.UniLaSalle, Agrosci Coll, AGHYLE UP 2018 C101, Beauvais, France
6.Zhejiang Univ, Hainan Inst, Sanya, Peoples R China
7.Univ Wisconsin, Dept Plant & Agroecosyst Sci, Madison, WI 53706 USA
期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）
ISSN：
年卷期： 2025 年 16 卷 1 期
页码：
收录情况： SCI
摘要： Non-Mendelian transmission of mitochondria has been well established across most eukaryotes, however the genetic mechanism that governs this uniparental inheritance remains unclear. Plants in the genus Cucumis, specifically melon and cucumber, exhibit paternal transmission of the mitochondrial (mt) DNA, making them excellent models for exploring the molecular mechanisms underlying mitochondrial transmission. Here, we develop a toolkit to screen for mutants in mitochondrial inheritance (mti), and use fine mapping to successfully identify a mitochondrially targeted endonuclease gene (MTI1) controlling mitochondrial transmission. Knockout of MTI1 results in a shift from paternal to bi-parental inheritance of the mtDNA, confirming the crucial role of MTI1 in uniparental inheritance of mitochondria. Moreover, we demonstrate that MTI1 exhibits robust endonuclease activity both in vitro and in vivo, specifically expresses in mitochondria of the fertilized ovule within 24 h of pollination. Collectively, this study reveals that a nuclear-encoded but mitochondria-targeted gene plays a causative role in governing the non-Mendelian mitochondrial inheritance, revolutionizing our knowledge about mitochondrial DNA transmission.
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