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Genomic analysis reveals the population structure and antimicrobial resistance of avian Pasteurella multocida in China

文献类型： 外文期刊

作者： Jiang, Nansong 1 ; Chen, Hongmei 1 ; Cheng, Longfei 1 ; Fu, Qiuling 1 ; Liu, Rongchang 1 ; Liang, Qizhang 2 ; Fu, Guanghua 1 ; Wan, Chunhe 1 ; Huang, Yu 1 ;

作者机构： 1.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Res Ctr Poultry Dis, Fuzhou, Fujian, Peoples R China

2.Fujian Key Lab Prevent & Control Avian Dis, Fuzhou, Fujian, Peoples R China

3.Fujian Ind Technol Innovat Res Acad Livestock & Po, Fuzhou, Fujian, Peoples R China

期刊名称：JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY （ 影响因子：5.2； 五年影响因子：5.4 ）

ISSN： 0305-7453

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Objectives To investigate the population structure and antimicrobial resistance (AMR) of avian Pasteurella multocida in China.Methods Utilizing WGS analysis, we explored the phylogeny using a dataset of 546 genomes, comprising avian P. multocida isolates from China (n = 121), the USA (n = 165), Australia(n = 153), Bangladesh (n = 3) and isolates of other hosts from China (n = 104). We examined the integrative and conjugative element (ICE) structures and the distribution of their components carrying resistance genes, and reconstructed the evolutionary history of A:L1:ST129 (n = 110).Results The population structure of avian P. multocida in China was dominated by the A:L1:ST129 clone with limited genetic diversity. A:L1:ST129 isolates possessed a broader spectrum of resistance genes at comparatively higher frequencies than those from other hosts and countries. The novel putative ICEs harboured complex resistant clusters that were prevalent in A:L1:ST129. Bayesian analysis predicted that the A:L1:ST129 clone emerged around 1923, and evolved slowly.Conclusions A:L1:ST129 appears to possess a host predilection towards avian species in China, posing a potential health threat to other animals. The complex AMR determinants coupled with high frequencies may strengthen the population dominance of A:L1:ST129. The extensive antimicrobial utilization in poultry farming and the mixed rearing practices could have accelerated AMR accumulation in A:L1:ST129. ICEs, together with their resistant clusters, significantly contribute to resistance gene transfer and facilitate the adaptation of A:L1:ST129 to ecological niches. Despite the genetic stability and slow evolution rate, A:L1:ST129 deserves continued monitoring due to its propensity to retain resistance genes, warranting global attention to preclude substantial economic losses.

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