1A genome-wide CRISPR/Cas9 gene knockout screen identifies immunoglobulin superfamily DCC subclass member 4 as a key host factor that promotes influenza virus endocytosis

作者： Song, Yangming; Chen, Hualan; Song, Yangming; Huang, Haixiang; Hu, Yuzhen; Zhang, Jiwen; Li, Fang; Yin, Xin; Shi, Jianzhong; Li, Yanbing; Li, Chengjun; Zhao, Dongming; Chen, Hualan; SCI

机构： Gansu Agr Univ, Coll Vet Med, Lanzhou, Peoples R China; Chinese Acad Agr Sci, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R China;

来源：PLOS PATHOGENS

年份：2021

2Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication

作者： Luo, Weiyu; Zhang, Jie; Liang, Libin; Wang, Guangwen; Li, Qibing; Zhu, Pengyang; Zhou, Yuan; Li, Junping; Zhao, Yuhui; Sun, Nan; Huang, Shanyu; Zhou, Chenchen; Chang, Yu; Cui, Pengfei; Chen, Pucheng; Jiang, Yongping; Deng, Guohua; Bu, Zhigao; Li, Chengjun; Jiang, Li; Chen, Hualan; SCI

机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Heilongjiang, Peoples R China; Chinese Acad Agr;

来源：PLOS PATHOGENS

年份：2018

3Avian influenza vaccines against H5N1 'bird flu'

作者： Li, Chengjun; Bu, Zhigao; Chen, Hualan; SCI

机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150001, Peoples R China;

来源：TRENDS IN BIOTECHNOLOGY

关键词： H5N1 avian influenza vaccine.

4The nucleoprotein and matrix protein segments of H5N1 influenza viruses are responsible for dominance in embryonated eggs

作者： Shimizu, Kenta; Muramoto, Yukiko; Yamada, Shinya; Kawaoka, Yoshihiro; Shimizu, Kenta; Arikawa, Jiro; Li, Chengjun; Kawaoka, Yoshihiro; Chen, Hualan; Chen, Hualan; Kawaoka, Yoshihiro; Kawaoka, Yoshihiro; Kawaoka, Yoshihiro; SCI

机构： Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol, Tokyo, Japan; Hokkaido Univ, Grad Sch Med, Dept Microbiol, Sapporo, Hokkaido 060, Japan; Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA; Chinese Acad Agr Sci, Minist Agr, Anim Influenza Lab, Harbin, Peoples R China; Chinese Acad Agr Sci, Harbin Vet Res Inst, Natl Key Lab Vet Biotechnol, Harbin, Peoples R China; Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Tokyo, Japan; Kobe Univ, Grad Sch Med, Dept Microbiol & Infect Dis, Div Zoonosis, Kobe, Hyogo, Japan; Japan Sci & Technol Agcy, ERATO Infect Induced Host Responses Project, Saitama, Japan;

来源：JOURNAL OF GENERAL VIROLOGY

5Complex Reassortment of Multiple Subtypes of Avian Influenza Viruses in Domestic Ducks at the Dongting Lake Region of China

作者： Deng, Guohua; Tan, Dan; Shi, Jianzhong; Cui, Pengfei; Jiang, Yongping; Liu, Liling; Tian, Guobin; Li, Chengjun; Chen, Hualan; Kawaoka, Yoshihiro; SCI

机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China; Univ Tokyo, Inst Med Sci, Tokyo, Japan;

来源：JOURNAL OF VIROLOGY

6Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals

作者： Liang, Libin; Jiang, Li; Li, Junping; Zhao, Qingqing; Wang, Jinguang; He, Xijun; Huang, Shanyu; Wang, Qian; Zhao, Yuhui; Wang, Guangwen; Sun, Nan; Deng, Guohua; Shi, Jianzhong; Tian, Guobin; Zeng, Xianying; Jiang, Yongping; Liu, Liling; Liu, Jinxiong; Chen, Pucheng; Bu, Zhigao; Chen, Hualan; Li, Chengjun; Kawaoka, Yoshihiro; SCI

机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Heilongjiang, Peoples R China; Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol, Tokyo, Japan;

来源：MBIO

关键词： ANP32A; avian influenza virus; H7N9; PB2 E627K mutation; viral PA protein; viral adaptation in mammals; viral polymerase

年份：2019

7Amino Acid Mutations A286V and T437M in the Nucleoprotein Attenuate H7N9 Viruses in Mice

作者： Ma, Shujie; Zhang, Bo; Shi, Jianzhong; Yin, Xin; Wang, Guangwen; Cui, Pengfei; Liu, Liling; Deng, Guohua; Jiang, Yongping; Li, Chengjun; Chen, Hualan; SCI

机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Heilongjiang, Peoples R China;

来源：JOURNAL OF VIROLOGY

关键词： H7N9; genetic basis; influenza; virulence

年份：2020

8The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry

作者： Wang, Guangwen; Jiang, Li; Wang, Jinliang; Zhang, Jie; Kong, Fandi; Li, Qibing; Yan, Ya; Huang, Shanyu; Zhao, Yuhui; Liang, Libin; Li, Junping; Sun, Nan; Hu, Yuzhen; Shi, Wenjun; Deng, Guohua; Chen, Pucheng; Liu, Liling; Zeng, Xianying; Tian, Guobin; Bu, Zhigao; Chen, Hualan; Li, Chengjun; SCI

机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Heilongjiang, Peoples R China;

来源：JOURNAL OF VIROLOGY

关键词： beta-arrestin1; AP2B1; FFAR2; GRK; entry; influenza A virus; internalization

年份：2020

9A single-amino-acid mutation at position 225 in hemagglutinin attenuates H5N6 influenza virus in mice

作者： Kong, Xingtian; Chen, Hualan; Kong, Xingtian; Guan, Lizheng; Shi, Jianzhong; Kong, Huihui; Zhang, Yaping; Zeng, Xianying; Tian, Guobin; Liu, Liling; Li, Chengjun; Deng, Guohua; Chen, Hualan; Kawaoka, Yoshihiro; SCI

机构： Gansu Agr Univ, Coll Vet Med, Lanzhou, Peoples R China; Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China; Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol, Tokyo, Japan;

来源：EMERGING MICROBES & INFECTIONS

关键词： Influenza virus; molecular basis; pathogenicity; mice

年份：2021

10H7N9 virus infection triggers lethal cytokine storm by activating gasdermin E-mediated pyroptosis of lung alveolar epithelial cells

作者： Wan, Xiaopeng; Li, Jiqing; Yu, Xiaofei; He, Xijun; Shi, Jianzhong; Deng, Guohua; Zeng, Xianying; Tian, Guobin; Li, Yanbing; Jiang, Yongping; Guan, Yuntao; Li, Chengjun; Chen, Hualan; Wang, Yupeng; Shao, Feng; SCI

机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150069, Peoples R China; Natl Inst Biol Sci, Beijing 102206, Peoples R China;

来源：NATIONAL SCIENCE REVIEW

关键词： H7N9 virus; cytokine storm; gasdermin E; pyroptosis

年份：2022