1Validated hydrophilic interaction LC-MS/MS method for simultaneous quantification of dacarbazine and 5-amino-4-imidazole-carboxamide in human plasma

作者： Yang, Yuhui; Zhang, Weihua; Liu, Yanhong; SCI

机构： Chrom Matrix Inc, Richland, WA 99354 USA; Gansu Prov Canc Hosp, Lanzhou 730001, Peoples R China; Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Minist Agr, Key Lab Anim Virol,State Key Lab Vet Etiol Biol, Lanzhou 730046, Peoples R China;

来源：TALANTA

关键词： Dacarbazine 5-Amino-4-imidazole-carboxamide Matrix effect Carryover Hydrophilic interaction chromatography LC-MS/MS Primary and secondary amine Pharmacokinetics METASTATIC MELANOMA METABOLITE 5-AMINOIMIDAZOLE-4-CARBOXAMIDE INTERACTION CHROMATOGRAPHY MASS-SPECTROMETRY ION SUPPRESSION PHARMACOKINETICS EXTRACTION CHEMOTHERAPY