Rational design, synthesis and binding mechanisms of novel benzyl geranate derivatives as potential eco-friendly aphid repellents

文献类型： 外文期刊

第一作者： Pan, Shi-Xiang

作者： Pan, Shi-Xiang;Yang, Zhao-Kai;Liu, Yan;Shi, Zhuo;Zhou, Zheng-Xin;Yang, Xin-Ling;Qin, Yao-Guo;Qin, Yao-Guo;Qu, Cheng;Luo, Chen;Li, Xue-Sheng;Yang, Xin-Ling

作者机构：

关键词： rational design; eco-friendly aphid-repellent; plant volatile organic compounds; odorant-binding proteins

期刊名称：PEST MANAGEMENT SCIENCE （ 影响因子：4.1； 五年影响因子：4.4 ）

ISSN： 1526-498X

年卷期： 2023 年

页码：

收录情况： SCI

摘要： BACKGROUNDThe push-pull strategy is considered as a promising eco-friendly method for pest management. Plant volatile organic compounds (PVOCs) act as semiochemicals constitute the key factor in implementing this strategy. Benzyl alcohol and geraniol, as functional PVOCs, were reported to regulate insect behavior, showing the potential application in pest control. Using geraniol as lead, a geraniol derivative 5i with fine repellent activity was discovered in our previous work. In order to explore novel, eco-friendly aphid control agents, a series of benzyl geranate derivatives was designed and synthesized using 5i as the lead and benzyl alcohol as the active fragment.RESULTSBenzyl alcohol was firstly evaluated to have repellent activity to Acyrthosiphon pisum. Based on this repellent fragment, a series of novel benzyl geranate derivatives was rationally designed and synthesized using a scaffold-hopping strategy. Among them, compound T9, with a binding affinity (Kd = 0.43 mu m) and a substantial repellency of 64.7% against A. pisum, is the most promising compound. Molecule docking showed that hydrophobic and hydrogen-bonding interactions substantially influenced the binding affinity of compounds with ApisOBP9. Additionally, T9 exhibited low-toxicity to honeybees and ladybugs.CONCLUSIONUsing a simple scaffold-hopping strategy combined with active fragment benzyl alcohol, a new derivative T9, with high aphid-repellency and low-toxicity to nontarget organisms, can be considered as a novel potential eco-friendly aphid control agent for sustainable agriculture. (c) 2023 Society of Chemical Industry. A novel benzyl geranate compound T9 was rationally discovered as an eco-friendly aphid repellent by scaffold-hopping strategy based on the active fragment of benzyl alcohol, and its mechanism was elucidated.image

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