Phylogeography Analysis Reveals Rabies Epidemiology, Evolution, and Transmission in the Philippines

文献类型： 外文期刊

第一作者： Zhang, Liang

作者： Zhang, Liang;Jiang, Jianfeng;Gong, Wenjie;Zhang, Liang;Sun, Sheng;Liu, Yan;Tu, Changchun;Gong, Wenjie;Feng, Ye;Cruz, Jeffrey;Gonzales, Riva Marie;Azul, Rachel R.;Pena, Rainelda C. Dela;Tian, Yao;Jiang, Tao;Fang, Liqun;Feng, Ye;Wang, Yuyang;Tu, Changchun

作者机构：

关键词： rabies virus; Philippines; molecular epidemiology; transmission patterns; selection pressure; strategy

期刊名称：MOLECULAR BIOLOGY AND EVOLUTION （ 影响因子：5.3； 五年影响因子：11.9 ）

ISSN： 0737-4038

年卷期： 2025 年 42 卷 2 期

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收录情况： SCI

摘要： Rabies, caused by rabies virus, is a severe public health problem in the Philippines, where animal rabies epidemiology had been extensively investigated, but little is known about the national epidemiologic situations since 2010. Here, we report a 12-year nationwide animal rabies surveillance with systematic phylogenetic analysis, in which 353 whole genomes of rabies viruses collected from animal rabies cases between 2018 and 2022 were obtained. The phylogenetic and spatial-temporal evolutionary analyses showed that rabies viruses in the Philippines were exclusively classified into the SEA4 subclade within the Asian clade, but forming three major geographically specific lineages. Intra-island spread predominates the rabies transmission in three major island regions, while the inter-island transmission, between major island regions, is very limited, likely due to ocean barriers. Overall, our findings have provided the most comprehensive dataset on the infected animal species, geographic distribution, transmission dynamics, genetic diversity of rabies viruses, and transmission risk factors, thus established a basis to support WOAH-endorsed national control program for dog-mediated rabies in the Philippines.

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