Facile fabricate sandwich-structured molecularly imprinted dopamine polymer for simultaneously specific capture of Low-density lipoprotein and eliminate "bad cholesterol"

文献类型： 外文期刊

第一作者： Cao, Jianfang

作者： Cao, Jianfang;Liu, Yaobo;Wang, Weiting;Du, Pengfei;Ma, Yanli;Liu, Gang;Wang, Yuanshang

作者机构：

关键词： Sandwich-type; Molecular imprinting; Imprinted cavity; Simultaneously specific capture; Low-density lipoprotein

期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.1； 五年影响因子：3.7 ）

ISSN： 0021-9673

年卷期： 2024 年 1724 卷

页码：

收录情况： SCI

摘要： A simplified approach for preparation of sandwich type molecularly imprinted polymers (PPDA-MIPs) is proposed for simultaneously identify Low-density lipoprotein (LDL) and dispose "bad cholesterol". Porous polydopamine nanosphere (PPDA) is applied as a matrix for immobilization of LDL, and the imprinted layer is formed by dopamine acting as a functional monomer. Since imprinted cavities exhibit shape memory effects in terms of recognizing selectivity, the PPDA-MIPs exhibit excellent selectivity toward LDL and a substantial binding capacity of 550.3 mu g mg-1. Meanwhile, six adsorption/desorption cycles later, the adsorption efficiency of 83.09 % is still achieved, indicating the adequate stability and reusability of PPDA-MIPs. Additionally, over 80 % of cholesterol is recovered, indicating the completeness of "bad cholesterol" removal in LDL. Lastly, as demonstrated by gel electrophoresis, PPDA-MIPs performed satisfactory behavior for the removal of LDL from the goat serum sample.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序