Effects of a polysaccharide extract from Amomum villosum Lour. on gastric mucosal injury and its potential underlying mechanism

文献类型： 外文期刊

第一作者： Liu, Huifan

作者： Liu, Huifan;Zhuang, Shanshan;Liang, Churong;Ma, Lukai;Xiao, Gengsheng;He, Junjun;Brennan, Charles Stephen;Brennan, Margert Anne;Ma, Lukai;Chen, Hao;Wan, Shuo

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关键词： Amomum villosum Lour. polysaccharide; Structure characterization; Alcohol-induced; Gastric mucosal injure; Mechanism

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：10.723； 五年影响因子：9.964 ）

ISSN： 0144-8617

年卷期： 2022 年 294 卷

页码：

收录情况： SCI

摘要： AVLP-2, a novel acidic polysaccharide, was isolated and purified from Amomum villosum Lour. The structural characteristics of the polysaccharides were characterized using monosaccharide composition, methylation, FT-IR, and NMR techniques. Results showed that AVLP-2 comprises galactose and glucose monomers, has a mo-lecular weight of 10.488 kDa, and has backbone structures -> 4)-alpha-D-GalAp-(1 -> 3,4)-alpha-D-GalAp-(1 ->, -> 4)-alpha-D- GalAp-(1 -> 6)-alpha-D-Galp-(1 ->, and n -> 6)-alpha-D-Galp-(1 -> 4)-alpha-D-Glcp-(1 ->, with alpha-D-Galp-(1 -> branches. Furthermore, AVLP-2 had a significant protective effect against oxidative stress in alcohol-induced injury and LPS inflam-mation models GES-1 cells by regulating the levels of ROS and inflammatory factors. In the animal experiments, AVLP-2 improved the oxidative stress status of the gastric mucosa by increasing SOD activity and GSH levels and inhibiting the excessive generation of malondialdehyde in tissues. The levels of MPO, IL-1 beta, IL-10, and NF-kappa B p65 were downregulated, while that of TNF-alpha was upregulated by AVLP-2 treatment, thereby reducing the alcohol -induced inflammation.

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