miR-140-3p promotes follicle granulosa cell proliferation and steroid hormone synthesis via targeting AMH in chickens

文献类型： 外文期刊

第一作者： Zhang, Bei -Bei

作者： Zhang, Bei -Bei;Li, Xue-Nan;Li, Meng-Xiao;Shi, Yu -Xiang;Ma, Teng-He;Sun, Yan-Yan

作者机构：

关键词： Chicken; Granulosa cells; MiR-140-3p; anti-M?llerian hormone; Steroid hormone

期刊名称：THERIOGENOLOGY （ 影响因子：2.8； 五年影响因子：2.6 ）

ISSN： 0093-691X

年卷期： 2023 年 202 卷

页码：

收录情况： SCI

摘要： Granulosa cells (GCs) are the ovary's most critical cells since they undergo cell differentiation and hor-mone synthesis changes closely associated with follicle development. While micro RNA 140-3p (miRNA-140-3p) has an apparent cell signaling role, particularly in cell proliferation, its biological role in chicken ovarian follicle growth and development remains elusive. This study explored miR-140-3p's effects on chicken GC proliferation and steroid hormone synthesis. MiR-140-3p dramatically increased GC prolif-eration, prevented apoptosis, increased progesterone synthesis, and enhanced gene expression related to steroid hormone synthesis. In addition, the anti-Mullerian hormone (AMH) gene was identified as a direct miR-140-3p target. MiR-140-3p abundance correlated negatively with AMH mRNA and protein levels in GCs. Our findings show that miR-140-3p influences chicken GC proliferation and steroid hor-mone synthesis by suppressing AMH expression.(c) 2023 Elsevier Inc. All rights reserved.

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