Genetic and Biological Properties of an Epidemic Feline Panleukopenia Virus Strain (Ala91Ser) in China
文献类型： 外文期刊
第一作者： Feng, Erkai
作者： Feng, Erkai;Ye, Zihan;Yan, Manping;Zhou, Yaxi;Wu, Danni;Cheng, Shipeng;Cheng, Yuening
作者机构：
关键词： Ala91Ser; epidemic; feline panleukopenia virus; immunogenicity; pathogenicity
期刊名称：VETERINARY SCIENCES （ 影响因子：2.3； 五年影响因子：2.4 ）
ISSN：
年卷期： 2025 年 12 卷 7 期
页码：
收录情况： SCI
摘要： To genetically characterise an epidemic isolate of feline panleukopenia virus (FPLV) harbouring the Ala91Ser mutation in China, a clinical strain (accession number: OR921195.1), named FPLV-CC19-02, was isolated from a PCR-positive faecal swab sample. Phylogenetic analysis revealed that it is far removed from all current commercial vaccine strains and differs from the FPLV prototype strain Cu-4 (M38246.1), specifically the vaccine strain of Fel-O-Vax (R) PCT, at positions 91 (Ala91Ser) and 101 (Ile101Thr) within the VP2 protein. This virus can induce the typical cytopathic effect seen in parvovirus infection in feline kidney cells, resulting in severe clinical symptoms in cats, including haematochezia and hyperthermia. Furthermore, infected cats died of virus infection within 5-10 days post-infection (dpi) (100% morbidity and 83% mortality), indicating that FPLV-CC19-02 is a strain with increased virulence. Additionally, it demonstrated good immunogenicity in cats. Overall, these findings may help us to better understand the molecular prevalence of feline panleukopenia virus in cats and provide valuable basic data for the development of effective, locally adapted feline panleukopenia virus vaccines in China.
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