A review on Zika vaccine development

文献类型： 外文期刊

第一作者： Peng, Zhe-Yu

作者： Peng, Zhe-Yu;Lu, Hong-Zheng;Wang, Lin-Min;Li, Ni;Zhang, Hai-Ting;Xing, Si-Yu;Du, Yi-Nan;Deng, Sheng-Qun;Yang, Song

作者机构：

关键词： Zika virus; Mosquito-borne disease; Vaccine

期刊名称：PATHOGENS AND DISEASE （ 影响因子：3.3； 五年影响因子：3.3 ）

ISSN： 2049-632X

年卷期： 2024 年 82 卷

页码：

收录情况： SCI

摘要： Zika virus (ZIKV), which belongs to the Flavivirus family, is mainly transmitted via the bite of Aedes mosquitoes. In newborns, ZIKV infection can cause severe symptoms such as microcephaly, while in adults, it can lead to Guillain-Barre syndrome (GBS). Due to the lack of specific therapeutic methods against ZIKV, the development of a safe and effective vaccine is extremely important. Several potential ZIKV vaccines, such as live attenuated, inactivated, nucleic acid, viral vector, and recombinant subunit vaccines, have demonstrated promising outcomes in clinical trials involving human participants. Therefore, in this review, the recent developmental progress, advantages and disadvantages of these five vaccine types are examined, and practical recommendations for future development are provided. This review help readers fully understand the current progression of ZIKV vaccine and enhance the awareness of the prevention of ZIKV.

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