Use of an improved version of C-8+SCX mixed mode solid phase extraction material for clean extraction and recovery of basic and zwitterionic compounds from biological fluids

文献类型： 外文期刊

第一作者： Liu, YH

作者： Liu, YH

作者机构：

关键词： C-8+SCX mixed mode;solid phase extraction (SPE);systematic toxicology analysis;illegal drug;CHROMATOGRAPHY-MASS-SPECTROMETRY;PERFORMANCE LIQUID-CHROMATOGRAPHY;BOND-ELUT CERTIFY;SYSTEMATIC TOXICOLOGICAL ANALYSIS;NITROGEN-PHOSPHORUS DETECTION;LINKED-IMMUNOSORBENT-ASSAY;SINGLE-COLUMN PROCEDURE;GAS-CHROMATOGRAPHY;WHOLE-BLOOD;HAIR ANALYSIS

期刊名称：JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES （ 影响因子：1.312； 五年影响因子：1.145 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Mixed mode bonded silica, containing both reversed phase and cationic exchange compositions, is one of the most versatile solid phase extraction (SPE) products in the market due to generic extraction methods and some successful applications for cleaner extraction of basic compounds from biological fluids. However, the present study shows that many zwitterions compounds and polar basic compounds cannot be effectively extracted and recovered from the current C-8+SCX mixed mode products. The inability is due to too low an ion exchange capacity. In order to solve the problem, the SCX functional coverage is optimized to develop an improved version of C-8+SCX mixed mode material. Three generic extraction protocols have been categorized. The first one is used to completely recover basic and zwitterions compounds with some hydro-phobicity, and this protocol offers the cleanest background. The second one is used to recover polar basic and zwitterions compounds, and/or the third one is used to systematically fractionate basic and zwitterions compounds from neutral and acidic compounds for further analysis. The considerable advance greatly improves the performance of cationic mixed mode SPE products and the corresponding data reproducibility.

分类号： O65

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