Preparation, characterization and cytotoxic activity of selenium nanoparticles stabilized with a heteropolysaccharide isolated from Sanghuangporus vaninii residue

文献类型： 外文期刊

第一作者： Chu, Wenqi

作者： Chu, Wenqi;Liu, Peng;Zhang, Zhong;Wu, Di;Li, Wen;Chen, Wanchao;Li, Zhengpeng;Yang, Yan;Wang, Weike;Chu, Wenqi

作者机构：

关键词： Edible fungi; Polysaccharide; Selenium nanoparticles; Antitumor effect

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：10.7； 五年影响因子：10.2 ）

ISSN： 0144-8617

年卷期： 2024 年 343 卷

页码：

收录情况： SCI

摘要： Selenium nanoparticles (SeNPs) possess unique features with excellent bioavailability and bioactivity, but the poor stability limits its application. A combination of polysaccharides and SeNPs is an effective strategy to overcome the limitation. Herein, a heteropolysaccharide (SVL-3) with an average molecular weight of 2.428 x 104 Da was purified from the fruiting body residue of Sanghuangporus vaninii after soaking in sorghum wine, which was composed of fucose, galactose, glucose, fructose and 3-O-methyl-galactose. The main chain of SVL-3 was composed of -> 6)-alpha-3-MeO-Galp-(1 ->, -> 4)-alpha-D-Galp-(1 ->, -> 2,6)-beta-D-Glcp-(1 -> and -> 3)-alpha-D-Glcp-(1 ->, and the branched chain was composed of -> 4)-alpha-D-Xylp-(1 -> and alpha-L-Fucp-(1 ->. For enhancing bioactivity of SVL-3 and stability of SeNPs, SVL-3-functionalized SeNPs (SVL-3-SeNPs) was prepared, which contained 45.31 % polysaccharide and 48.49 % selenium. SVL-3-SeNPs maintained an emphatic stability over 28 days at 4 degrees C and pH 6-8, and exhibited a higher cytotoxic effect on MCF-7 cells than SVL-3 and SeNPs. The inhibitory effect of SVL-3-SeNPs on the cancer cells may be associated with the mechanisms by inducing S-phase arrest, triggering apoptosis and elevating the protein levels of Cytochrome c, Caspases and cleaved caspases 3 and 9. These results indicated that SeNPs modified by S. vaninii polysaccharides can be utilized as a potential material for targeted antitumor drugs.

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