Homo/Hetero-Dimers of Aromatic Bisabolane Sesquiterpenoids with Neuroprotective Activity from the Fungus Aspergillus versicolor A18 from South China Sea

文献类型： 外文期刊

第一作者： Weng, Han-Zhuang

作者： Weng, Han-Zhuang;Zhu, Jun-Yu;Yuan, Fang-Yu;Tang, Zhuo-Ya;Chen, Ye;Tang, Gui-Hua;Yin, Sheng;Tian, Xiao-Qing;Fan, Cheng-Qi

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关键词： diphenyl ether-coupled aromatic bisabolane; aromatic bisabolane dimer; marine-derived fungus; Aspergillus versicolor; neuroprotective activity

期刊名称：MARINE DRUGS （ 影响因子：6.085； 五年影响因子：6.044 ）

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年卷期： 2022 年 20 卷 5 期

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收录情况： SCI

摘要： Chromatographic fractionation of the EtOH extracts of the marine-derived fungus Aspergillus versicolor A18 has led to the isolation of 11 homo/hetero-dimers of aromatic bisabolane sesquiterpenoids including eight diphenyl ether-coupled aromatic bisabolanes (1a/1b and 5-10) and three homodimers (2-4), together with their monomers including three aromatic bisabolanes (11-13) and two diphenyl ethers (14 and 15). Their structures and absolute configurations were elucidated by extensive spectroscopic analysis including HRESIMS, 1D/2D NMR, calculated ECD, and the optical rotatory data. Among the four new compounds, (+/-)-asperbisabol A (1a/1b), asperbisabol B (2), and asperbisabol C (3), the enantiomers 1a and 1b represent an unprecedented skeleton of diphenyl ether-coupled aromatic bisabolane sesquiterpenoids with a spiroketal core moiety. The neuroprotective effects of selected compounds against sodium nitroprusside (SNP)-induced injury were evaluated in PC12 cells by the MTT assay. Five compounds (1a, 6, and 8-10) showed remarkable neuroprotective activities at 10 mu M, being more active than the positive control edaravone.

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