Comparison of the cross-protection of PPRSV sublineage 8.7 MLV vaccines against the recombinant NADC30-like strain

文献类型： 外文期刊

第一作者： Li, Jianda

作者： Li, Jianda;Wang, Yu;Ren, Sufang;Zhang, Yuyu;Guo, Lihui;Liu, Fei;Lv, Tingting;Jiao, Jian;Liu, Yanyan;Chen, Zhi;Sun, Wenbo;Yu, Jiang;Wu, Jiaqiang;Zhang, Yuyu;Lv, Tingting;Yang, Guiwen;Wu, Jiaqiang;Meng, Kai;Wang, Zhao;Wang, Yu;Peng, Jun

作者机构：

关键词： PRRSV; NADC30-like strain; Modified-live virus vaccine; Cross-protection; Epidemiology

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.3； 五年影响因子：3.5 ）

ISSN： 0378-1135

年卷期： 2023 年 281 卷

页码：

收录情况： SCI

摘要： The emergence of recombinant porcine reproductive and respiratory syndrome virus (PRRSV) has caused a substantial threat to the swine industry in recent years. However, the protective efficacy of different sublineage 8.7 PRRSV modified-live virus (MLV) vaccines against emerging strains were still obscure. In this study, a broad epidemiological investigation of PRRSV showed the prevalence of NADC30-like strain increased in Shandong Province, China from 2018 to 2020. Through piglet trial for vaccination and challenge with recombinant NADC30-like SDlz1601 strain, CH-1R MLV vaccine showed better protective effect than JXA1-R and TJM-F92 MLV vaccines in terms of clinical score and pathological observation. Moreover, all three MLV vaccines could reduce virus loads in the serum of piglets. This study provides valuable insights into the prevalence of the NADC30-like strain and the protective effect of PRRS MLV vaccines against recombinant NADC30-like strains, which could help to improve the prevention and control of PRRSV infections.

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