Protection of guinea pigs and swine by a recombinant adenovirus expressing O serotype of foot-and-mouth disease virus whole capsid and 3C protease

文献类型： 外文期刊

第一作者： Lu, Zengjun

作者： Lu, Zengjun;Bao, Huifang;Cao, Yimei;Sun, Pu;Guo, Jianhun;Li, Pinghua;Bai, Xingwen;Chen, Yingli;Xie, Baoxia;Li, Dong;Liu, Zaixin;Me, Qingge

作者机构：

关键词： humoral immune response;cellular immune response

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Two recombinant adenoviruses were constructed expressing foot-and-mouth disease virus (FMDV) capsid and 3C/3CD proteins in replicative deficient human adenovirus type 5 vector. Guinea pigs vaccinated with 1-3 x 10(8) TCID50 Ad-P12 x 3C recombinant adenovirus were completely protected against 10,000 GID(50) homologous virulent FMDV challenge 25 days post vaccination (dpv). Ad-P12 x 3CD vaccinated guinea pigs were only partially protected. Swine were vaccinated once with 1 x 10(9) TCID50 Ad-P12 x 3C hybrid virus and challenged 28 days later. Three of four vaccinated swine were completely protected against 200 pig 50% infectious doses (ID50) of homologous FMDV challenge, and vaccinated pigs developed specific cellular and humoral immune responses. The immune effect of Ad-P12 x 3C in swine further indicated that the recombinant adenovirus was highly efficient in transferring the foreign gene. This approach may thus be a very hopeful tool for developing FMD live virus vector vaccine. (c) 2008 Elsevier Ltd. All rights reserved.

分类号： R194

  • 相关文献

[1]Recombinant pseudorabies virus expressing P12A and 3C of FMDV can partially protect piglets against FMDV challenge. Zhang, Keshan,Wang, Qingang,He, Yannan,Xu, Zhuofei,Xiang, Min,Wu, Bin,Chen, Huanchun,Zhang, Keshan,Huang, Jiong.

[2]Immunogenicity of a cell culture-derived inactivated vaccine against a common virulent isolate of grass carp reovirus. Zeng, Weiwei,Li, Shoujun,Zeng, Weiwei,Wang, Qing,Wang, Yingying,Zhao, Changchen,Li, Yingying,Shi, Chunbin,Wu, Shuqin,Song, Xinjian,Huang, Qiwen.

作者其他论文 更多>>

微信小程序