Health functions and related molecular mechanisms of Miconia genus: A systematic review

文献类型： 外文期刊

第一作者： Gandhi, Sathiyabama Rajiv

作者： Gandhi, Sathiyabama Rajiv;Quintans, Jullyana de Souza Siqueira;Quintans Junior, Lucindo Jose;Gandhi, Gopalsamy Rajiv;Gurgel, Ricardo Queiroz;Quintans, Jullyana de Souza Siqueira;Quintans Junior, Lucindo Jose;Gandhi, Gopalsamy Rajiv;Hillary, Varghese Edwin;Ceasar, Stanislaus Antony;Antony, Poovathumkal James;Hariharan, Govindasamy;Liu, Yi;Quintans Junior, Lucindo Jose

作者机构：

关键词： Miconia; Therapeutic mechanism; Animal model; Antioxidant; Analgesic; Anti-inflammatory

期刊名称：HELIYON （ 影响因子：4.0； 五年影响因子：4.1 ）

ISSN：

年卷期： 2023 年 9 卷 3 期

页码：

收录情况： SCI

摘要： The Miconia genus is traditionally used in folk medicine in Brazil and other tropical American countries and is represented by 282 species in this region. It is a multifaceted genus of medicinal plants widely used to treat rheumatoid arthritis (RA), pain, inflammatory diseases, and many more therapeutic applications. In the present study, we systematically identify and discuss the literature on in vivo and in vitro studies focusing on the therapeutic potentials and related mo-lecular mechanisms of the Miconia genus. The review also assessed phytochemicals and their pharmacological properties and considered safety concerns related to the genus. Literature searches to identify studies on the Miconia genus were carried out through four main electronic databases, namely PubMed, Embase, Scopus, and Web of Science limited to Medical Subjects Headings (MeSH) and Descriptores en Ciencias de la Salud (DCS) (Health Sciences Descriptors) to identify studies published up to December 2022. The relevant information about the genus was gathered using the keywords 'Miconia', 'biological activities', 'therapeutic mechanisms', 'animal model, 'cell-line model', 'antinociceptive', 'hyperalgesia', 'anti-inflammatory', and 'inflamma-tion'. The therapeutic potentials and mechanisms of action of 14 species from genus Miconia were examined in 18 in vitro studies and included their anti-inflammatory, anticancer, analgesic, antibacterial, cytotoxic, mutagenic, antioxidant, anti-leishmanial, antinociceptive, schistosomi-cidal, and anti-osteoarthritis potentials, and in eight in vivo studies, assessing their analgesic, antioxidant, antinociceptive, and anti-osteoarthritis activities. Some of the main related molec-ular mechanisms identified are the modulation of cytokines such as IL-1 beta, IL-6, and TNF-alpha, as well as the inhibition of inflammatory mediators and prostaglandin synthesis. The limited number of studies showed that commonly available species from the genus Miconia are safe for consumption. Miconia albicans Sw.Triana and Miconia rubiginosa (Bonpl.) DC was the most frequently used species and showed significant efficacy and potential for developing safe drugs to treat pain and inflammation.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序