Neuroprotective effects of dendrobium endophytes metabolites in SH-SY5Y cells via the Nrf2/Keap1 pathway

文献类型： 外文期刊

第一作者： Liu, Jia meng

作者： Liu, Jia meng;Qin, Lu qi;Lu, Cong;Sun, Jing;Wang, Qiong;Fan, Bei;Wang, Feng zhong;Liu, Jia meng;Qin, Lu qi;Lu, Cong;Sun, Jing;Wang, Qiong;Fan, Bei;Wang, Feng zhong;Liang, Yan tian;Yang, Yong

作者机构：

关键词： Dendrobium endophytes; Neuroprotection; SH-SY5Y; Oxidative stress; Nrf2

期刊名称：HELIYON （ 影响因子：4.0； 五年影响因子：4.1 ）

ISSN：

年卷期： 2024 年 10 卷 6 期

页码：

收录情况： SCI

摘要： Recent studies have revealed that endophytes in plants can produce metabolites with activity that is comparable to or identical to the host. Dendrobine has attracted much attention in the field of neurodegenerative diseases by exhibiting anti-oxidative stress and neuroprotective effects. This study aimed to investigate the protective effects and mechanisms of metabolites of dendrobium endophytes Pseudomonas protegens CM-YJ44 and Priestia megaterium D-HT207 against H2O2induced oxidative stress injury in SH-SY5Y cells. Results showed that there were 50 neuroprotective compounds in CM-YJ44 and 72 neuroprotective compounds in D-HT207. Those both increased significantly cell viability, decreased contents of ROS in H2O2-induced SH-SY5Y cells. It was confirmed that metabolites of CM-YJ44 and D-HT207 inhibited the H2O2-induced oxidative stress injury in SH-SY5Y cells, which mechanism is related to inhibition of ROS production, alteration of MMP, and inhibition of apoptosis and inflammatory factors expression via the Nrf2/ Keap1 pathway.

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