Novel Function of Avian p53 in Binding to ALV-J LTR Contributes to Its Antiviral Roles

文献类型： 外文期刊

第一作者： Duan, Yueyue

作者： Duan, Yueyue;Gao, Yulong;Wang, Xiaomei;Duan, Yueyue;Cao, Liyan;Yuan, Cong;Suo, Xuepeng;Kong, Xiangyu;Li, Xiangtong;Zheng, Haixue;Wang, Qi;Duan, Yueyue;Cao, Liyan;Yuan, Cong;Suo, Xuepeng;Kong, Xiangyu;Li, Xiangtong;Wang, Qi;Duan, Yueyue;Cao, Liyan;Yuan, Cong;Suo, Xuepeng;Kong, Xiangyu;Li, Xiangtong;Wang, Qi

作者机构：

关键词： histone deacetylase; p53; viral replication

期刊名称：MBIO （ 影响因子：7.786； 五年影响因子：8.483 ）

ISSN： 2150-7511

年卷期： 2022 年 13 卷 1 期

页码：

收录情况： SCI

摘要： Accumulating evidence suggests that p53 is involved in viral infection. However, it remains elusive whether avian p53 orchestrates avian leukosis virus (ALV) replication. We showed that p53 recruits the histone deacetylase 1 and 2 (HDAC1/2) complex to the ALV promoter to shut off ALV's promoter activity and viral replication. HDAC1/2 binding to the ALV promoter was abolished in the absence of p53. Moreover, we collected samples in ALV-infected chickens and found that the acetylation status of ALV-bound H3 and H4 histones correlated with ALV viremia. HDAC inhibitors (HDACi) potently increase ALV replication, but HDACi-promoted viral replication is dramatically reduced in cells with p53 depletion. These data demonstrate that p53 is critical for inhibition ALV replication and suggest that future studies of ALV replication need to account for the potential effects of p53 activity. IMPORTANCE Rous sarcoma virus (RSV)/ALV was the first retrovirus to be discovered, which was really the first hint that cancer, or a tumor, could be transmitted by a virus. The specific mechanisms that regulate ALV replication during infection remain poorly understood. Here, we show that avian p53 and HDAC complex inhibit ALV promoter activity and replication, and p53 inhibits ALV replication through binding to the ALV promoter. We demonstrated that the acetylation status of ALV-bound H3 and H4 his tones correlates with ALV viremia level using clinical samples collected from commercial poultry. These findings identify both p53-mediated inhibition on ALV replication and a potential role for virus-induced tumorigenesis.

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[1]Novel Function of Avian p53 in Binding to ALV-J LTR Contributes to Its Antiviral Roles. Duan, Yueyue,Gao, Yulong,Wang, Xiaomei,Duan, Yueyue,Cao, Liyan,Yuan, Cong,Suo, Xuepeng,Kong, Xiangyu,Li, Xiangtong,Zheng, Haixue,Wang, Qi,Duan, Yueyue,Cao, Liyan,Yuan, Cong,Suo, Xuepeng,Kong, Xiangyu,Li, Xiangtong,Wang, Qi,Duan, Yueyue,Cao, Liyan,Yuan, Cong,Suo, Xuepeng,Kong, Xiangyu,Li, Xiangtong,Wang, Qi. 2022

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