Gastrointestinal biotransformation and tissue distribution of pterostilbene after long-term dietary administration in mice

文献类型： 外文期刊

第一作者： Sun, Yue

作者： Sun, Yue;Sun, Yue;Wang, Qi;Wu, Xian;Li, Fang;Song, Mingyue;Wang, Minqi;Cai, Xiaokun;Li, Zhengze;Gao, Zili;Zheng, Jinkai;Qi, Ce;Sun, Jin;Xiao, Hang;Wu, Xian;Song, Mingyue;Zheng, Jinkai;Qi, Ce;Sun, Jin

作者机构：

关键词： Pterostilbene; Pinostilbene; Biotransformation; Microbiota; Metabolites

期刊名称：FOOD CHEMISTRY （ 影响因子：9.231； 五年影响因子：8.795 ）

ISSN： 0308-8146

年卷期： 2022 年 372 卷

页码：

收录情况： SCI

摘要： The metabolic fate of dietary compounds is closely related to their biological functions. Pterostilbene (PT) is a methylated stilbene found in many plant foods. Herein, we investigated gastrointestinal biotransformation and tissue distribution of PT in mice fed with 0.05% PT (w/w) for 5 weeks. PT and its major metabolites i.e. PT sulfate (PT-S), pinostilbene, pinostilbene sulfate, hydroxylated PT and hydroxylated PT sulfate were identified and quantified in the mucosa and content of the digestive tissues, blood, urine and vital organs. The results showed PT underwent demethylation, hydroxylation and conjugation in the small intestine, while the conjugated metabolites were largely deconjugated in the colon. Anaerobic fermentation with mouse cecal bacteria demonstrated the microbiota mediated deconjugation and demethylation of PT-S and PT, respectively. In conclusion, oral consumption of PT led to extensive biotransformation in mouse gastrointestinal tract and the metabolites of PT might play important roles in the bioactivity of PT.

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