Correlation of 20 Single-Nucleotide Polymorphisms with Weight and Wool Traits in Alpine Merino Sheep

文献类型： 外文期刊

第一作者： Xiao, Tong

作者： Xiao, Tong;Yue, Lin;Lu, Zengkui;Yuan, Chao;Song, Yali;Yang, Bohui;Liu, Jianbin;Guo, Tingting;Li, Yuhang;Lu, Zengkui;Yuan, Chao;Yang, Bohui;Liu, Jianbin;Guo, Tingting;Lu, Zengkui;Yuan, Chao;Yang, Bohui;Liu, Jianbin;Guo, Tingting

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关键词： Alpine Merino sheep; single-nucleotide polymorphisms; verification; important traits; polymorphisms

期刊名称：ANIMALS （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2024 年 14 卷 1 期

页码：

收录情况： SCI

摘要： SNPs associated with important traits of fine-wool sheep that were previously obtained through genome-wide association analysis screening were verified and analyzed. A total of 20 SNPs related to birth weight, bundle strength, cleaning rate, and fiber diameter were screened using whole-genome resequencing, and the SNPshot assay was used to detect and analyze polymorphisms. This study found that, among the 20 SNPs associated with important traits in Alpine Merino sheep, 8 were monomorphic and 12 were polymorphic, of which 6 showed moderate polymorphisms and 6 showed low polymorphisms. The heterozygosity of the 12 polymorphic loci ranged from 0.10 to 0.49, the effective number of alleles ranged from 1.11 to 1.98, and the polymorphic information content ranged from 0.09 to 0.37. The chi-square test showed that only RHPN2:g.42678119T>G and RALYL:g.90030866A>G were in Hardy-Weinberg disequilibrium (p < 0.05); the other loci were in equilibrium (p > 0.05). These SNPs associated with important traits in Alpine Merino sheep provide a theoretical basis for genomic selection and molecular design breeding.

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