Graphitic carbon nitride/methyl pyrophaeophorbide a-copper/folate nanoconjugate for enhanced immunogenic death combined with PD-L1 immune checkpoint blockades

文献类型： 外文期刊

第一作者： Qu, Chunyu

作者： Qu, Chunyu;Sun, Minghao;Wu, Xiaodan;Lan, Zhixiang;Tan, Guanghui;Wang, Zhiqiang;Jin, Yingxue;Zhang, Hui;Bao, Yujun;Jin, Siran

作者机构：

关键词： Methyl pyrophaeophorbide a; Graphitic carbon nitride (g-C 3 N 4 ); Copper ion; Immune checkpoint blocking therapy (ICB); Immunogenic cell death (ICD)

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.7； 五年影响因子：5.0 ）

ISSN： 1567-5769

年卷期： 2025 年 160 卷

页码：

收录情况： SCI

摘要： Immune checkpoint blockade (ICB) is a tumor therapy that leverages the activation mechanisms of T cells in the immune system. A key challenge in ICB is poor T-cell infiltration and low tumor immunogenicity. Immunogenic cell death (ICD) can increase tumor immunogenicity and make tumors more sensitive to ICB. Programmed death ligand 1 (PD-L1) a major target for ICB. In this paper, a novel carbon nitride/methyl pyrophaeophorbide a-copper/folate (abbreviated as CNMCF) nanocomposite was prepared for induced ICD. In CNMCF nanostructures, methyl pyrophaeophorbide a (MPPa) serves as the photodynamic therapy (PDT) agent, and copper ion serves as the chemodynamic therapy (CDT) agent. CNMCF not only induced ICD, but also alleviated tumor hypoxia. This led to down-regulation of hypoxia-inducing factor (HIF-1 alpha) and PD-L1, promoted T lymphocyte invasion, effectively enhanced tumor immunogenicity, and elicited strong anti-tumor immune response, thereby suppressing primary tumor growth and metastasis. This research expanded the application of natural chlorophyll derivatives and C3N4-based drug delivery systems in cancer immunotherapy.

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