Phenethoxy Derivatives with Anti-inflammatory Activities from the Betelnut Endophytic Trichoderma asperellum G10

文献类型： 外文期刊

第一作者： Chen, Ming-Yang

作者： Chen, Ming-Yang;Yu, Jing;Wu, You-Gen;Kong, Fan-Dong;Zhou, Li-Man;Yang, Li;Ma, Qing-Yun;Xie, Qing-Yi;Chen, Peng-Wei;Dai, Hao-Fu;Zhao, You-Xing

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.803； 五年影响因子：4.869 ）

ISSN： 0163-3864

年卷期： 2022 年 85 卷 5 期

页码：

收录情况： SCI

摘要： Eight new phenethoxy derivatives, trichoasperellinsA-H(1-8), were isolated from the endophytic fungusTrichoderma asperellumG10 isolated from the medicinal plantAreca catechuL. The structures of these compounds wereelucidated from spectroscopic data,J-based configurationalanalysis, and Mosher's methods. Compounds1-4and6-8bearone or two multioxidized C7moieties with the same carbonskeleton. The carbon skeletons of compounds6-8are new, allcontaining three moieties connected via two acetal carbons similarto those of disaccharide glycosides. Compound4inhibited nitricoxide production with an IC50value of 48.3 mu M, comparable to that of the positive control indomethacin (IC50, 42.3 mu M).

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