Non-Coding RNAs Regulate Spontaneous Abortion: A Global Network and System Perspective

文献类型： 外文期刊

第一作者： Gan, Jianyu

作者： Gan, Jianyu;Gu, Ting;Yang, Huaqiang;Cai, Gengyuan;Hong, Linjun;Wu, Zhenfang;Ao, Zheng;Cai, Gengyuan;Hong, Linjun;Wu, Zhenfang;Cai, Gengyuan;Hong, Linjun;Wu, Zhenfang

作者机构：

关键词： spontaneous abortion; miRNA; lncRNA; circRNA; competing endogenous RNA; systematic network

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）

ISSN：

年卷期： 2022 年 23 卷 8 期

页码：

收录情况： SCI

摘要： Spontaneous abortion is a common pregnancy complication that negatively impacts women's health and commercial pig production. It has been demonstrated that non-coding RNA (ncRNA) is involved in SA by affecting cell proliferation, invasion, apoptosis, epithelial-mesenchymal transformation (EMT), migration, and immune response. Over the last decade, research on ncRNAs in SA has primarily concentrated on micro RNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). In this review, we discuss recent ncRNA studies focused on the function and mechanism of miRNAs, lncRNAs, and circRNAs in regulating SA. Meanwhile, we suggest that a ceRNA regulatory network exists in the onset and development of SA. A deeper understanding of this network will accelerate the process of the quest for potential RNA markers for SA diagnosis and treatment.

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