Dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea / black mulberry leaf tea in mice
文献类型： 外文期刊
第一作者： Zhong, Shi
作者： Zhong, Shi;Huo, Jinxi;Sun, Yuqing;Ren, Ning;Lu, Qinhua;Li, Da;Wu, Weijie;Chen, Huizhi;Niu, Ben;Li, Qingsheng;Li, Yougui;Yang, Yanan;Wu, Chongming;Zhan, Pengfei;Pan, Meiliang;Ma, Huanyan;Liu, Qinqiao
作者机构： Zhejiang Acad Agr Sci, Hangzhou 310021, Peoples R China;Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China;Huzhou Acad Agr Sci, Huzhou Agr Technol Extens Ctr, Huzhou 313002, Peoples R China;Zhejiang Prov Dept Agr & Rural Affairs, Zhejiang Prov Ctr Agr Technol Extens, Hangzhou 310020, Peoples R China;Huzhou Liuyin Biol Technol Co LTD, Huzhou 313009, Peoples R China
关键词： Mulberry leaf; Mulberry tea; Lipid-lowering; Gut microbiota; Metabolomics
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 2022影响因子：5.6； 五年影响因子：5.3 ）
ISSN： 1756-4646
年卷期： 2023 年 111 卷
收录情况： SCI
摘要： Mulberry leaf has potential in lipid-lowering. Here, we compared the chemical composition and lipid-lowering effects of different mulberry leaf-derived teas, and investigated their underlying gut microbiome-related mechanisms. The main components of mulberry leaf-derived tea were flavonoids, phenolic acids and alkaloids, with green tea (0.60% polyphenols, 3.35% polysaccharides, 0.20% DNJ) containing higher levels than black tea (0.40% polyphenols, 2.95% polysaccharides, 0.15% DNJ). Accordingly, the lipid-lowering efficacy of green tea was superior to that of black tea in high-fat (HFD)-induced hyperlipidemic mice. Black tea increased 2 genera and 130 metabolites, decreased 6 genera and 90 metabolites, while green tea increased 5 genera and 127 metabolites, decreased 15 genera and 64 metabolites. Correlation analysis showed that the alterations of gut microbiota and metabolic profiles caused by mulberry leaf tea were tightly associated with its lipid-lowering effect. Altogether, this study provided a promising functional food targeting gut microbiota for the management of lipid metabolism.
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