文献类型： 外文期刊
第一作者： Wang, Chunqun
作者： Wang, Chunqun;Gupta, Nishith;Hu, Min;Gao, Wenjie;Liu, Xin;Gao, Wenjie;Yan, Shi;Zhu, Xing-Quan;Suo, Xun;Gupta, Nishith;Gupta, Nishith
作者机构：
关键词： Haemonchus contortus; N-glycosylation; N-glycan; Mass spectrometry; Glycopeptide
期刊名称：COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL （ 影响因子：7.271； 五年影响因子：7.409 ）
ISSN： 2001-0370
年卷期： 2021 年 19 卷
页码：
收录情况： SCI
摘要： N-glycosylation is a physiologically vital post-translational modification of proteins in eukaryotic organisms. Initial work on Haemonchus contortus - a blood-sucking nematode of ruminants with a broad geographical distribution - has shown that this parasite harbors N-glycans with exclusive chitobiose modifications. Besides, several immunogenic proteins (e.g., amino- and metallo-peptidases) are known to be N-glycosylated in adult worms. However, an informative atlas of N-glycosylation in H. contortus is not yet available. Herein, we report 291 N-glycosylated proteins with a total of 425 modification sites in the parasite. Among them, many peptidase families (e.g., peptidase C1 and M1) including potential vaccine targets were enriched. Notably, the glycan-rich conjugates are distributed primarily in the intestine and gonads of adult worms, and consequently hidden from the host's immune system. Collectively, these data provide a comprehensive atlas of N-glycosylation in a prevalent parasitic nematode while underlining its significance for infection, immunity and prevention. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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