Effect of cordyceps militaris on growth performance, antioxidant capacity, and intestinal epithelium functions in weaned pigs

文献类型： 外文期刊

第一作者： Li, YanPing

作者： Li, YanPing;Yu, Bing;Huang, Zhiqing;Luo, Yuheng;Zheng, Ping;Mao, Xiangbing;Yu, Jie;Luo, Junqiu;Yan, Hui;He, Jun;Li, YanPing;Yu, Bing;Huang, Zhiqing;Luo, Yuheng;Zheng, Ping;Mao, Xiangbing;Yu, Jie;Luo, Junqiu;Yan, Hui;He, Jun;Lu, Yang

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关键词： antioxidative capacity; cordyceps militaris; growth performance; intestinal function; weaned pigs

期刊名称：JOURNAL OF ANIMAL SCIENCE （ 影响因子：2.7； 五年影响因子：3.2 ）

ISSN： 0021-8812

年卷期： 2024 年 102 卷

页码：

收录情况： SCI

摘要： To explore the effects of cordyceps militaris (CM) on growth performance and intestinal epithelium functions, 180 weaned pigs were randomly assigned into 5 treatments with 6 replicate pens per treatment (6 pigs per pen). Pigs were fed with basal diet (control) or basal diet supplemented with 100, 200, 400, and 800 mg/kg CM. The trial lasted for 42 d, and pigs from the control and optimal-dose groups (based on growth performance) were picked for blood and tissue collection (n = 6). Results showed that CM elevated the average daily gain (ADG) and decreased the ratio of feed intake to gain (F:G) in the weaned pigs (P < 0.05). CM supplementation at 100 mg/kg improved the digestibilities of dry matter (DM), crude protein (CP), and gross energy (GE) (P < 0.05). CM not only increased the activities of superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) but also increased the concentration of interleukin-10 (IL-10) in serum (P < 0.05). The serum concentrations of malondialdehyde (MDA), d-lactate, and diamine oxidase (DAO) were reduced by CM (P < 0.05). Interestingly, CM elevated the villus height and the ratio of villus height to crypt depth in the duodenum and jejunum and increased the activities of duodenal sucrase and maltase (P < 0.05). Moreover, CM elevated the expression levels of tight-junction proteins ZO-1, claudin-1, and occluding, as well as critical functional genes such as the fatty acid transport protein (FATP1), cationic amino acid transporter 1 (CAT1), and NF-E2-related factor 2 (Nrf2) in the duodenum and jejunum (P < 0.05). Importantly, CM increased the concentrations of acetic acid and butyric acid, and elevated the abundances of Bacillus and Lactobacillus in the cecum and colon, respectively (P < 0.05). These results indicated potential benefits of CM in improving the growth of weaned pigs, and such effect may be tightly associated with improvement in antioxidant capacity and intestinal epithelium functions.

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