Prevalence, Molecular Characterization, and Antimicrobial Resistance Profile of Enterotoxigenic Escherichia coli Isolates from Pig Farms in China
文献类型： 外文期刊
第一作者： Zhu, Jiajia
作者： Zhu, Jiajia;Liu, Zewen;Wang, Siyi;Gao, Ting;Liu, Wei;Yang, Keli;Yuan, Fangyan;Wu, Qiong;Li, Chang;Guo, Rui;Tian, Yongxiang;Zhou, Danna;Wang, Siyi
作者机构：
关键词：
Enterotoxigenic
期刊名称：FOODS （ 影响因子：5.1； 五年影响因子：5.6 ）
ISSN：
年卷期： 2025 年 14 卷 7 期
页码：
收录情况： SCI
摘要： Enterotoxigenic Escherichia coli (ETEC) poses a critical threat to livestock health and food safety, particularly in regard to misuse of antimicrobial agents, which have accelerated the evolution of multidrug-resistant (MDR) ETEC strains, reshaping their virulence landscapes and epidemiological trajectories. In this study, 24 ETEC isolates from porcine diarrheal samples undergo genomic and phenotypic profiling, including virulence genotyping, bacterial adhesion, and antimicrobial resistance (AMR) analysis. Results show that multi-locus sequence typing (MLST) outputs (ST88, ST100) and serotypes (O9:H19, O116:H11, O149:H10) exhibited enhanced virulence, with F18ab-fimbriated strains carrying Shiga toxin genes (stx2A) demonstrating higher cytotoxicity than non-stx strains. There exists a significant negative correlation between bacterial growth rates and intestinal epithelial adhesion, with the expression of ETEC adhesion and virulence genes being growth-time-dependent. These relationships suggest evolutionary trade-offs favoring either rapid proliferation or virulence. Among these isolates, 95.8% were MDR, with alarming resistance to quinolones and aminoglycosides. Geospatial analysis identified region-specific AMR gene clusters, notably oqxB-aac(3) co-occurrence networks in 79% of ETEC isolates. These results highlight the urgent need for precision interventions, including vaccines targeting epidemic serotypes and AMR monitoring systems to disrupt resistance propagation across swine production networks. By underscoring the importance of current virulence and AMR profiles, this study provides actionable strategies to mitigate ETEC-associated threats to both animal welfare and meat safety ecosystems.
分类号：
- 相关文献
作者其他论文 更多>>
-
Genome-wide analysis of autophagy-related genes (ATGs) in banana highlights MaATG8s in cell death and autophagy in immune response to Fusarium wilt (vol 36, pg 1237, 2017)
作者：Wei, Yunxie;Liu, Guoyin;Wu, Chunjie;Liu, Wei;Zeng, Hongqiu;He, Chaozu;Shi, Haitao;Wei, Yunxie;Liu, Guoyin;Wu, Chunjie;Liu, Wei;Zeng, Hongqiu;He, Chaozu;Shi, Haitao;Liu, Wen;Hu, Wei
关键词：
-
Different Efficacy of Five Soluble Dietary Fibers on Alleviating Loperamide-Induced Constipation in Mice: Influences of Different Structural Features
作者：Zhang, Zhiguo;Liu, Buyu;Zhang, Chengcheng;Hu, Weiwei;Wu, Weicheng;Liu, Buyu;Liu, Xingquan;Liu, Wei
关键词：soluble dietary fiber; structural difference; constipation; defecation function; short-chain fatty acid; gut microbiota
-
The whole-genome dissection of root system architecture provides new insights for the genetic improvement of alfalfa (Medicago sativa L.)
作者：Jiang, Xueqian;Zeng, Xiangcui;Xu, Ming;Li, Mingna;Zhang, Fan;He, Fei;Long, Ruicai;Yang, Qingchuan;Kang, Junmei;Xu, Ming;Yang, Tianhui;Wang, Chuan;Gao, Ting;Yang, Tianhui
关键词：
-
External Sucrose Delays Pakchoi Senescence Through Regulating Energy Metabolism
作者：Wang, Siyi;Yang, Guangzhen;Ma, Yongqiang;Wang, Jiatao;Han, Chao;Yu, Zuolong;Fu, Changchun;Han, Yanchao
关键词：energy metabolism; pakchoi; quality; sucrose
-
Divergent Flowering Time Responses to Increasing Temperatures Are Associated With Transcriptome Plasticity and Epigenetic Modification Differences at FLC Promoter Region of Arabidopsis thaliana
作者：Han, Yu;Liu, Li;Lei, Mengyu;Si, Huan;Ji, Yan;Du, Qiao;Zhang, Wenjia;Zan, Yanjun;Han, Yu;Liu, Wei;Du, Qiao;Liu, Jianquan;Han, Yu;Liu, Wei;Du, Qiao;Liu, Jianquan;Zhu, Mingjia;Liu, Jianquan;Dai, Yifei
关键词：ecological adaptation; flowering time; gene co-expression network; plasticity
-
A wheat phytohormone atlas spanning major tissues across the entire life cycle provides novel insights into cytokinin and jasmonic acid interplay
作者：Yin, Huanran;Liu, Wei;Hu, Xin;Jia, Jingqi;Liu, Mengmeng;Wei, Jiaqi;Cheng, Yikeng;Gong, Xin;Li, Qiang;Yan, Wenhao;Chen, Wei;Jia, Jizeng;Gao, Lifeng;Fernie, Alisdair R.
关键词：wheat; phytohormones; metabolic regulatory network; DOF
-
Identification of Wheat Stripe Rust Inoculum Sources and Dispersal Routes Responsible for Initial Rust Establishment in Southern Henan of China
作者：Wang, Aolin;Jiang, Ru;Zhang, Meihui;Nie, Xiao;Huang, Liang;Liu, Wei;Fan, Jieru;Zhou, Yilin;Wang, Aolin;Hu, Xiaoping;Wang, Aolin;Hu, Xiaoping;Cao, Shiqin;Sun, Zhenyu;Peng, Hong;Xu, Fei;Xu, Xiangming
关键词：aeromycology; backward-trajectory calculations; epidemiological investigation; migration routes; source identification; wheat stripe rust
