文献类型： 外文期刊
第一作者： Xiong, Tianzhen
作者： Xiong, Tianzhen;Li, Xinmeng;Yue, Huidie;Liu, Junling;Bai, Dingyuan;Li, Wei;Fan, Guangyan;Xiong, Tianzhen;Li, Xinmeng;Yue, Huidie;Liu, Junling;Bai, Dingyuan;Li, Wei;Fan, Guangyan;Xiong, Tianzhen;Liu, Wei;Xiong, Tianzhen
作者机构：
关键词：
Hydroxytyrosol;
期刊名称：SCIENTIFIC REPORTS （ 影响因子：3.9； 五年影响因子：4.3 ）
ISSN： 2045-2322
年卷期： 2025 年 15 卷 1 期
页码：
收录情况： SCI
摘要： Hydroxytyrosol, a fine chemical, is widely utilized in food and pharmaceutical industries. In this study, we constructed a pathway to produce hydroxytyrosol by co-expressing tyrosin-phenol lyase (TPL), L-amino acid dehydrogenase (aadL), alpha-keto acid decarboxylase (KAD), aldehyde reductase (yahK) and glucose dehydrogenase (gdh). We changed combinations between plasmids with different copy numbers and target genes, resulting in 84% increase in hydroxytyrosol production. The yield of hydroxytyrosol was further increased 89.3% by optimizing the temperature and pH. Finally, 55.3 mM hydroxytyrosol was produced within 14 h by fed-batch biotransformation. This study provides a novel approach for hydroxytyrosol production.
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