Lactobacillus helveticus LZ-R-5 Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Enhancing Intestinal Barrier Function

文献类型： 外文期刊

第一作者： Zhao, Xiaogan

作者： Zhao, Xiaogan;Lin, Tao;Jiang, Wenkai;Xiao, Luyao;Tian, Yufang;Mahsa, Ghahvechi Chaeipeima;Rui, Xin;Li, Wei;Lin, Tao;Lin, Yihan;Ma, Kai;Zhang, Changliang;Ji, Feng;Ma, Kai;Zhang, Changliang;Ji, Feng

作者机构：

关键词： kefir; Lactobacillus helveticus; ulcerativecolitis; short-chain fatty acid; gut microbiota

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）

ISSN： 0021-8561

年卷期： 2025 年 73 卷 1 期

页码：

收录情况： SCI

摘要： Lactobacillus helveticus LZ-R-5 (R-5), a strain with high epithelial adhesion and bioactive exopolysaccharide production, was isolated from Tibetan kefir grains. This study investigated its potential to alleviate intestinal inflammation using a DSS-induced colitis model in BALB/c mice. We integrated microbial diversity and serological analyses to assess changes in gut flora and cytokines following the R-5 treatment. Pathological assessments showed that R-5 reduced crypt distortion in the proximal colon and mitigated hepatic immune challenges by enhancing gut barrier function. The increased relative expression of TGF-beta 1 and the downregulation of NLRP3-related inflammatory factors were conducive to preventing organ damage in the thymus and spleen of mice with colitis. Additionally, R-5 stimulated GPR43 expression and improved epithelial nutrition, promoting mucin production to prevent enterotoxin leakage. It also modulated the gut microbiota by suppressing Bacteroides and Erysipelatoclostridium, leading to a microbiota composition more akin to that of normal flora.

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