A novel pyrazoline-based fluorescent probe for Cu2+in aqueous solution and imaging in live cell

文献类型： 外文期刊

第一作者： Zhang, Ying-peng

作者： Zhang, Ying-peng;Zhao, Yu-chen;Xue, Qing-hua;Yang, Yun-shang;Guo, Hui-Chen;Guo, Hui-Chen;Xue, Ji-Jun;Xue, Ji-Jun

作者机构：

关键词： Pyrazoline; Cu2+fluorescent probe; Reversible recognition; Cell imaging

期刊名称：INORGANIC CHEMISTRY COMMUNICATIONS （ 影响因子：2.495； 五年影响因子：1.887 ）

ISSN： 1387-7003

年卷期： 2021 年 129 卷

页码：

收录情况： SCI

摘要： In this study, a new pyrazoline derivate (1-acetyl-3- (2-hydroxy-1-naphthyl)-5-(2-phenyl-2H-chromene)-2-pyrazoline, N) is described as fluorescent probe for fluorometric detection of Cu2+. This fluorescence of probe has a high selectivity only toward Cu2+ ion in the other metal ions. It is remarkably observed that the fluorescence intensity of N decreased in the presence of Cu2+ ions with a strong capability to resist perturbations. The Limit of detection (LOD) value is calculated as 8.85 x 10-7 M for Cu2+ while the complexation constant is calculated as 3.14 x 105 M-2 via fluorescence measurements. The interaction between of N and Cu2+ is reversible after adding PPi. The optimized calculation of the probe for Cu2+ is confirmed by TD-DFT calculations. N-Cu2 thorn is successfully applied in the intracellular imaging in living PK-21cells that will have a great chance for wide application.

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