Effects of different doses of free alpha-linolenic acid infused to the duodenum on the immune function of lactating dairy cows

文献类型: 外文期刊

第一作者: Sun, Peng

作者: Sun, Peng;Wang, Jiaqi;Yang, Guang;Liu, Qingsheng

作者机构:

关键词: IgG: immunoglobulin G;IgM: immunoglobulin M;interferon-gamma;interleukin-2: IL-2;Th1 cytokine;interleukin-4: IL-4;interleukin-10: IL-10;IgA: immunoglobulin A;free fatty acid;alpha-linolenic acid: 463-40-1;Th2 cytokine;prostaglandin E2: PGE2;363-24-6;immune function

期刊名称:ARCHIVES OF ANIMAL NUTRITION ( 影响因子:2.242; 五年影响因子:2.601 )

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收录情况: SCI

摘要: This study investigated the effect of a duodenal infusion of a C18:3 free fatty acid on the immune function of lactating dairy cows. Four primiparous Chinese Holstein cows fitted with duodenal cannulas received 0, 100, 200, 300, and 400g/d of -linolenic acid (LNA) in a two-treatment crossover design. Blood was collected and serum IgA, IgG, IgM, prostaglandin E-2 (PGE(2)) and Th1/Th2 cytokines were determined. Results showed that increasing the supply of LNA to the small intestine of dairy cows linearly increased serum IgG and quadratically enhanced interferon-alpha (p < 0.05), whereas the concentrations of PGE(2) declined linearly (p < 0.05) and those of interleukin (IL)-4 tended to decrease (p = 0.08). No difference was observed in serum IgA, IgM or other cytokines, such as IL-2, IL-6 and IL-10. This study demonstrated that in dairy cows, a post-ruminal infusion of high doses of LNA has immunomodulatory effects, possibly associated with a predisposition to a Th1-type response.

分类号: S8

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