A facile synthesis of novel thiazolo[4,5-d]pyrimidin-7-ones

文献类型： 外文期刊

第一作者： Liang, Ying

作者： Liang, Ying;Yang, Zi-Wen;Liang, Ying;He, Hong-Wu

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期刊名称：JOURNAL OF HETEROCYCLIC CHEMISTRY （ 影响因子：2.193； 五年影响因子：1.645 ）

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收录情况： SCI

摘要： Sixteen 5-alkylamino-3,6-diaryl-2-thioxo-2,3,6,7-tetrahydrothiazolo[4,5-d] pyrimidin-7-ones 4a-4p were designed and easily synthesized via a tandem aza-Wittig reaction. The iminophosphorane 2, obtained from reaction of 1 with triphenylphosphine, hexachloroethane and Et3N, reacted with aromatic isocyanate to give carbodiimide 3. carbodiimide 3 reacted with alkylamines to provide the title compounds in 45-61% isolated yields in presence of catalytic amount of ethoxide. The structures of compounds 4 were confirmed by 1H NMR, IR, MS, and elemental analysis.

分类号： O62

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