Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori

文献类型： 外文期刊

第一作者： Zhang, Zuofa

作者： Zhang, Zuofa;Shi, Liangen;Zhang, Zuofa

作者机构：

关键词： Nervous System: Neural Coordination;Immune System: Chemical Coordination and Homeostasis;Pharmacognosy: Pharmacology

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice Cis-mulberroside A (25 and 50 mg/kg) given by p o route 30 min before challenge produced a dose-dependent inhibition of the acetic acid-induced pain and Evans blue leakage in mice In addition, this compound exhibited significant systemic anti-inflammatory activity in carrageenan-induced mouse paw edema in a concentration-related manner (33 1 -68 5% inhibition), and similar results were achieved in formalin test Suppressive effects of cis-mulberroside A on the production of NO and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated macrophages were also assessed Collectively, cis-mulberroside A showed high analgesic and anti-inflammatory activities The above results will be the supporting evidence for the potential anti-rheumatoid activity of R mori in Chinese traditional medicine

分类号： S759.82

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