Optimization of polymerization parameters for the sorption of oseltamivir onto molecularly imprinted polymers

文献类型: 外文期刊

第一作者: Yang, Yajun

作者: Yang, Yajun;Li, Jianyong;Liu, Yurong;Zhang, Jiyu;Li, Bing;Cai, Xuepeng

作者机构:

关键词: LC-MS/MS;Molecularly imprinted polymer (MIP);Oseltamivir;Polymerization optimization;Selectivity;Uniform design

期刊名称:ANALYTICAL AND BIOANALYTICAL CHEMISTRY ( 影响因子:4.142; 五年影响因子:3.863 )

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收录情况: SCI

摘要: Molecularly imprinted polymers (MIPs) are tailor-made polymers with high selectivity for a given analyte, or group of structurally related compounds. The influence of the process parameters (the moles of functional monomer and cross-linker, the selection of functional monomer and solvent) on the preparation of oseltamivir (OS)-imprinted polymers was investigated. A mathematical method for uniform design to optimize these selected parameters and to increase the MIP selectivity for template molecules was applied. The optimal conditions to synthesize MIP were 0.69 mmol 30% acrylamide (AA) + 70% 4-Vinylpyridine (4-VP) and 5.0 mmol ethylene glycol dimethacrylate (EGDMA) copolymerized in 5 ml toluene in the presence of 0.1 mmol OS. MIP showed high affinity and selectivity for separation of the template molecule from other compounds. In the present study, we have established an effective LC-MS/MS method to identify and quantify OS with good sensitivity, accuracy and precision. [Figure not available: see fulltext.]

分类号: O65

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