Optimization of polymerization parameters for the sorption of oseltamivir onto molecularly imprinted polymers
文献类型: 外文期刊
第一作者: Yang, Yajun
作者: Yang, Yajun;Li, Jianyong;Liu, Yurong;Zhang, Jiyu;Li, Bing;Cai, Xuepeng
作者机构:
关键词: LC-MS/MS;Molecularly imprinted polymer (MIP);Oseltamivir;Polymerization optimization;Selectivity;Uniform design
期刊名称:ANALYTICAL AND BIOANALYTICAL CHEMISTRY ( 影响因子:4.142; 五年影响因子:3.863 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Molecularly imprinted polymers (MIPs) are tailor-made polymers with high selectivity for a given analyte, or group of structurally related compounds. The influence of the process parameters (the moles of functional monomer and cross-linker, the selection of functional monomer and solvent) on the preparation of oseltamivir (OS)-imprinted polymers was investigated. A mathematical method for uniform design to optimize these selected parameters and to increase the MIP selectivity for template molecules was applied. The optimal conditions to synthesize MIP were 0.69 mmol 30% acrylamide (AA) + 70% 4-Vinylpyridine (4-VP) and 5.0 mmol ethylene glycol dimethacrylate (EGDMA) copolymerized in 5 ml toluene in the presence of 0.1 mmol OS. MIP showed high affinity and selectivity for separation of the template molecule from other compounds. In the present study, we have established an effective LC-MS/MS method to identify and quantify OS with good sensitivity, accuracy and precision. [Figure not available: see fulltext.]
分类号: O65
- 相关文献
作者其他论文 更多>>
-
Effects of Different Tillage Measures Combined with Straw Returning on Soil Enzyme Activity and Microbial Community Structure and Diversity
作者:Xiao, Sa;Li, Bing;Zhang, Tingting;Luo, Jianzhu;Wang, Jie;Li, Juan;Zhang, Dejian;Xiao, Sa;Li, Bing;Zhang, Tingting;Luo, Jianzhu;Wang, Jie;Li, Juan;Zhang, Dejian;Zhang, Xiangqian
关键词:tillage methods; straw returning; enzyme activity; microbial biomass; microbial diversity
-
CsCIPK20 Improves Tea Plant Cold Tolerance by Modulating Ascorbic Acid Synthesis Through Attenuation of CsCSN5-CsVTC1 Interaction
作者:Di, Taimei;Wu, Yedie;Wang, Jie;He, Mingming;Huang, Jianyan;Li, Nana;Hao, Xinyuan;Ding, Changqing;Zeng, Jianming;Yang, Yajun;Wang, Xinchao;Wang, Lu
关键词:ascorbic acid; CsCIPK20; CsVTC1; low temperature
-
CsCBF1/CsZHD9-CsMADS27, a critical gene module controlling dormancy and bud break in tea plants
作者:Hao, Xinyuan;Tang, Junwei;Chen, Yao;Huang, Chao;Zhang, Weifu;Liu, Ying;Wang, Lu;Ding, Changqing;Yang, Yajun;Wang, Xinchao;Chen, Yao;Yue, Chuan;Liu, Ying;Dai, Wenhao;Horvath, David P.
关键词:bud dormancy; bud break; MADS-box; gene function; regulatory network;
Camellia sinensis -
Deleted in malignant brain tumors 1 (DMBT1) gene relate to immune priming and phagocytosis modulation in the small abalone Haliotis diversicolor
作者:Yao, Tuo;Tan, Junyuan;Lu, Jie;Fu, Shengli;Xie, Zhilv;Cheng, Changhong;Ye, Lingtong;Tan, Junyuan;Xie, Zhilv;Li, Bing
关键词:Abalone; DMBT1; Innate immunity; Phagocytic activity; Reinfection
-
Integration of RPA and CRISPR-Cas13a collateral activity for one-step detection of DHAV-3: A biological macromolecule-enabled diagnostic platform
作者:Zhao, Saisai;Zhang, Jiahao;Yu, Shumin;He, Dalin;Fan, Yaru;Liu, Guocheng;Diao, Youxiang;Li, Bing;Tang, Yi
关键词:CRISRPR/Cas13; RPA-CRISPR Cas13a; Lateral flow assay; Duck hepatitis a virus 3
-
Synergistic pathogenicity of novel duck Orthoreovirus and salmonella typhimurium in ducks
作者:Li, Bing;Mao, Mingtian;Li, Huihui;Wu, Mian;Lu, Chengguang;Lu, Meixi;Guo, Zhanbao;Liang, Suyun;Zhou, Zhengkui;Hou, Shuisheng;Tang, Yi;Man, Xinhong;Yuan, Mengdi;Diao, Youxiang
关键词:Novel Duck Orthoreovirus; Salmonella Typhimurium; Co-infection; Co-pathogenicity
-
Monosaccharides, dietary fiber, bioactive compounds, functional properties and volatile compounds in both clear and cloudy kiwi juices with oligosaccharides addition fermented by Lactobacillus helveticus
作者:Wang, Chengxin;Wang, Zining;Lei, Hongjie;Zhang, Ting;Xu, Kang;Li, Bing
关键词:Kiwi juices; Oligosaccharides; Lactobacillus helveticus; Bioactive compounds; Functional properties; Volatile compounds