Deoxynivalenol: Emerging Toxic Mechanisms and Control Strategies, Current and Future Perspectives

文献类型： 外文期刊

第一作者： Deng, Ying

作者： Deng, Ying;Wu, Qinghua;Wei, Wei;You, Li;Wang, Xu;Wu, Wenda;Wu, Wenda;Kuca, Kamil;Wu, Qinghua;Kuca, Kamil

作者机构：

关键词： deoxynivalenol; lncRNA; miRNA; Wnt/beta-catenin; brain-gut axis; biodegradation

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2023 年 71 卷 29 期

页码：

收录情况： SCI

摘要： Deoxynivalenol (DON) is the most frequently present mycotoxin contaminant in food and feed, causing a variety of toxic effects in humans and animals. Currently, a series of mechanisms involved in DON toxicity have been identified. In addition to the activation of oxidative stress and the MAPK signaling pathway, DON can activate hypoxia-inducible factor-1 alpha, which further regulates reactive oxygen species production and cancer cell apoptosis. Noncoding RNA and signaling pathways including Wnt/beta-catenin, FOXO, and TLR4/NF-kappa B also participate in DON toxicity. The intestinal microbiota and the brain-gut axis play a crucial role in DON-induced growth inhibition. In view of the synergistic toxic effect of DON and other mycotoxins, strategies to detect DON and control it biologically and the development of enzymes for the biodegradation of various mycotoxins and their introduction in the market are the current and future research hotspots.

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