Polysaccharide from Scutellaria baicalensis Georgi alleviates ulcerative colitis in mice by maintaining the intestinal barrier integrity via MLC/Notch signaling

文献类型： 外文期刊

第一作者： Xiao, Liang

作者： Xiao, Liang;Chen, Yongpo;Li, Xiaoqing;Li, Shuwei;Tang, Wenjie;Yan, Jiayou;Wei, Xiaolan;Zhou, Mengjia;Huang, Chongbo;Diao, Hui;Li, Shuwei;Tang, Wenjie;Yan, Jiayou;Wei, Xiaolan;Zhou, Mengjia;Huang, Chongbo;Diao, Hui

作者机构：

关键词： ulcerative colitis; Scutellaria baicalensis Georgi; polysaccharides; intestinal barrier; notch; myosin

期刊名称：CANADIAN JOURNAL OF ANIMAL SCIENCE （ 影响因子：1.0； 五年影响因子：1.3 ）

ISSN： 0008-3984

年卷期： 2025 年 105 卷

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收录情况： SCI

摘要： Ulcerative colitis is a chronic idiopathic inflammatory bowel disease (IBD) that seriously impacts human health. So far, little information has been reported on the possible benefits of polysaccharides from Scutellaria baicalensis Georgi (SBGP) in alleviating colitis. Therefore, our study investigated the potential therapeutic effects of SBGP on mice with DSS-induced colitis. Results showed that SBGP administration ameliorated the severity of clinical symptoms and enhanced immunomodulatory effects in dextran sulfate sodium (DSS)-treated mice. Additionally, SBGP was found to regulate the inflammatory response, improve mucosal barrier integrity, and maintain tight junctions in the colonic epithelium. Furthermore, SBGP was found to restrain the activation of Notch and MLCK/MLC signaling pathways, which play important roles in inflammation and epithelial barrier homeostasis. These findings suggest that SBGP may have therapeutic potential for the treatment of colitis and other IBD.

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