Astaxanthin biosynthesis for functional food development and space missions

文献类型： 外文期刊

第一作者： Xie, Xiulan

作者： Xie, Xiulan;Zhong, Moyu;Huang, Xinxin;Yuan, Xinrui;Ren, Maozhi;Huang, Xinxin;Ren, Maozhi;Mahna, Nasser;Mussagy, Cassamo Ussemane

作者机构：

关键词： Astaxanthin; microalgae; Haematococcuspluvialis; synthetic biology; cell factory; genetic engineering; human health; space exploration

期刊名称：CRITICAL REVIEWS IN BIOTECHNOLOGY （ 影响因子：7.7； 五年影响因子：10.1 ）

ISSN： 0738-8551

年卷期： 2025 年 45 卷 4 期

页码：

收录情况： SCI

摘要： Astaxanthin (AXT), a natural carotenoid, has strong antioxidant and anti-ageing effects and can reduce ultraviolet light-induced damage to cells and DNA, stimulate the immune system, and improve cardiovascular disease prognosis. Despite its wide applications in the: nutraceutical, cosmetic, aquaculture, and pharmaceutical industries, AXT industrial production and application are hindered by natural source scarcity, low production efficiency, and high requirements. This review compares the qualitative differences of AXT derived from different natural sources, evaluates the upstream procedures for AXT expression in different chassis organisms, and investigates synthetic biology- and cell factory-based strategies for the industrial production of natural AXT. Synthetic biology is a promising novel strategy for reprogramming plants or microorganisms to produce AXT. Additionally, genetic engineering using cell factories extends beyond terrestrial applications, as it may contribute to the long-term sustainability of human health during space exploration and migration endeavors. This review provides a theoretical basis for the efficient and accurate genetic engineering of AXT from the microalga Haematococcuspluvialis, providing a valuable reference for future research on the biomanufacturing of AXT and other biological metabolites.

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