Effect comparison of inulin with different molecular weights ameliorating intracerebral neuroinflammation induced by advanced glycation end products (AGEs) in diabetic mice

文献类型： 外文期刊

第一作者： Du, Fangling

作者： Du, Fangling;Xu, Tongcheng

作者机构：

期刊名称：FOOD & FUNCTION （ 影响因子：5.4； 五年影响因子：6.1 ）

ISSN： 2042-6496

年卷期： 2025 年 16 卷 13 期

页码：

收录情况： SCI

摘要： Inulin is widely recognized for reducing glucose levels in diabetes mellitus, but its role in concurrent diabetic encephalopathy has rarely been reported. In this study, type 2 diabetic KK-Ay mice were administered inulin with different molecular weights for 10 weeks. Intriguingly, a significant decrease in the level of inflammatory factors IL-1 beta and A beta protein deposition occurred in brain tissue based on immunofluorescence analysis when the mice were treated with inulin with different molecular weights, especially in the H (5-10 kDa) group, indicating that inulin was beneficial for ameliorating intracerebral neuroinflammation. RNA-seq analysis indicated that this effect might be related to the inactivation of the RAGE-mediated inflammatory pathway. Based on ELISA and western blot analysis, inulin in the H group significantly decreased AGEs content and downregulated the expression of RAGE as well as downstream NF kappa B and its phosphorylation, validating the above speculation. This was attributed to the fact that inulin has excellent scavenging ability of AGEs intermediate dicarbonyl compounds to block the glycation reaction, according to the in vitro BSA-FRU model analysis. Gut microbes such as Desulfovibrionaceae also contributed to the degradation of AGEs in vivo. In conclusion, this study highlighted a new application perspective of inulin in the treatment of diabetic complications.

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