Comparative effects of hawthorn (Crataegus pinnatifida Bunge) pectin and pectin hydrolyzates on the cholesterol homeostasis of hamsters fed high-cholesterol diets

文献类型： 外文期刊

第一作者： Zhu, Ru-Gang

作者： Zhu, Ru-Gang;Sun, Yan-Di;Li, Tuo-Ping;Peng, Xue;Duan, Wen-Bin;Zheng, Zheng-Zheng;Shi, Shu-Lei;Xu, Jing-Guo;Liu, Yan-Hua;Jin, Xiao-Yi;Chen, Gang

作者机构：

关键词： Haw pectin; Haw pectin hydrolyzates; Haw pectin pentasaccharide; Cholesterol homeostasis; Hamster

期刊名称：CHEMICO-BIOLOGICAL INTERACTIONS （ 影响因子：5.168； 五年影响因子：4.924 ）

ISSN： 0009-2797

年卷期： 2015 年 238 卷

页码：

收录情况： SCI

摘要： This study aims to compare the effects of feeding haw pectin (HP), haw pectin hydrolyzates (HPH), and haw pectin pentasaccharide (HPPS) on the cholesterol metabolism of hypercholesterolemic hamsters induced by high-cholesterol diets. The animals were fed a standard diet (SD), high-cholesterol diet (HCD), or HCD plus HP, HPH, or HPPS at a dose of 300 mg/kg body weight for 4 weeks. Results showed that HPPS was more effective than HP and HPH in decreasing the body weight gain (by 38.2%), liver weight (by 16.4%), and plasma and hepatic total cholesterol (TC; by 23.6% and 27.3%, respectively) of hamsters. In addition, the bile acid levels in the feces were significantly higher by 39.8% and 132.8% in the HPH and HPPS groups than in the HCD group. Such changes were not noted in the HP group. However, the HP group had higher cholesterol excretion capacities than the HPH and HPPS groups by inhibiting cholesterol absorption in the diet, with a 21.7% increase in TC excretion and a 31.1% decrease in TC absorption. Thus, HPPS could be a promising anti-atherogenic dietary ingredient for the development of functional food to improve cholesterol metabolism. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

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